Brief validation of the novel GeneXpert Xpress SARS-CoV-2 PCR assay

被引：36

作者：

Goldenberger, Daniel ^{[1
,2
]}

Leuzinger, Karoline ^{[3
]}

Sogaard, Kirstine K. ^{[1
,2
,4
]}

Gosert, Rainer ^{[3
]}

Roloff, Tim ^{[1
,2
,4
]}

Naegele, Klaudia ^{[3
]}

Cuenod, Aline ^{[4
]}

Mari, Alfredo ^{[4
]}

Seth-Smith, Helena ^{[1
,2
,4
]}

Rentsch, Katharina ^{[5
]}

Hinic, Vladimira ^{[1
,2
]}

Hirsch, Hans H. ^{[3
,6
,7
]}

Egli, Adrian ^{[1
,2
,4
]}

机构：

[1] Univ Hosp Basel, Lab Med, Clin Bacteriol & Mycol, Basel, Switzerland

[2] Univ Basel, Basel, Switzerland

[3] Univ Hosp Basel, Lab Med, Clin Virol, Basel, Switzerland

[4] Univ Basel, Dept Biomed, Lab Med, Appl Microbiol Res, Basel, Switzerland

[5] Univ Hosp Basel, Lab Med, Basel, Switzerland

[6] Univ Hosp Basel, Infect Dis & Hosp Epidemiol, Basel, Switzerland

[7] Univ Basel, Dept Biomed, Transplantat & Clin Virol, Basel, Switzerland

来源：

JOURNAL OF VIROLOGICAL METHODS | 2020年 / 284卷

关键词：

SARS-CoV-2; COVID-19; GeneXpert; Respiratory infection; Viruses; Diagnostics; PCR; NAT; COBAS; 6800;

D O I：

10.1016/j.jviromet.2020.113925

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The clinical and epidemiologic management of the SARS-CoV-2 pandemic is critically dependent on molecular assays with short turn-around time. We validated the novel Xpert Xpress SARS-CoV-2 assay using a commercial nucleic acid testing (Roche Cobas 6800). We found an excellent concordance over a range of SARS-CoV-2 loads and across established human coronaviruses.

引用

页数：3

共 6 条

[1]

Cepheid, 2021, Xpert Xpress SARS-CoV-2/Flu/RSV: Instruction for Use

[2] Detection of SARS-CoV-2 by Use of the Cepheid Xpert Xpress SARS-CoV-2 and Roche cobas SARS-CoV-2 Assays [J].

Moran, Angelica ;

Beavis, Kathleen G. ;

Matushek, Scott M. ;

Ciaglia, Carol ;

Francois, Nina ;

Tesic, Vera ;

Love, Nedra .

JOURNAL OF CLINICAL MICROBIOLOGY, 2020, 58 (08)

[3] The impact of point-of-care testing for influenza A and B on patient flow and management in a medical assessment unit of a general hospital [J].

O'Connell, S. ;

Conlan, C. ;

Reidy, M. ;

Stack, C. ;

Mulgrew, A. ;

Baruah, J. .

BMC RESEARCH NOTES, 2020, 13 (01)

[4] Viral load of SARS-CoV-2 in clinical samples [J].

Pan, Yang ;

Zhang, Daitao ;

Yang, Peng ;

Poon, Leo L. M. ;

Wang, Quanyi .

LANCET INFECTIOUS DISEASES, 2020, 20 (04) :411-412

[5] Laboratory Diagnosis of COVID-19: Current Issues and Challenges [J].

Tang, Yi-Wei ;

Schmitz, Jonathan E. ;

Persing, David H. ;

Stratton, Charles W. .

JOURNAL OF CLINICAL MICROBIOLOGY, 2020, 58 (06)

[6] Comparative evaluation of three Preprocessing Methods for extraction and detection of Influenza A Virus Nucleic Acids from sputum [J].

Yu, Fei ;

Qiu, Ting ;

Zeng, Ying ;

Wang, Yiyin ;

Zheng, Shufa ;

Chen, Xiao ;

Chen, Yu .

FRONTIERS IN MEDICINE, 2018, 5

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