Brugada-syndrome - diagnosis via 12-lead-ECG in a patient with fever and syncope

被引：0

作者：

Goetz, O. ^{[2
]}

Beckmann, B. ^{[1
]}

Kaab, S. ^{[1
]}

Hinterseer, M. ^{[1
]}

机构：

[1] Univ Munich, Klinikum Grosshadern, Med Klin & Poliklin 1, D-81377 Munich, Germany

[2] Univ Munich, Klinikum Grosshadern, Klin Anasthesiol, D-81377 Munich, Germany

来源：

NOTFALL & RETTUNGSMEDIZIN | 2009年 / 12卷 / 01期

关键词：

12-lead ECG; Sudden cardiac death; Brugada syndrome; Syncope; Fever; ST SEGMENT ELEVATION; BUNDLE-BRANCH BLOCK; SUDDEN-DEATH; CRITERIA; RISK;

D O I：

10.1007/s10049-008-1115-8

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

The case of a 27-year-old male patient with syncope during an episode of fever is presented. Preclinical 12-lead ECG showed typical features of Brugada syndrome with elevated ST segments in lead V1-V3. These ECG patterns disappeared when the body temperature returned to normal after fever reduction therapy. Further diagnostics with an ajmaline test confirmed the diagnosis of Brugada syndrome, a rare disease associated in 30% of cases with mutations in genes encoding the SCN5A myocardial sodium channel with a high risk for arrhythmia. An implantable cardioverter-defibrillator (ICD) was implanted in the patient after ventricular tachycardia was inducible during electrophysiological testing.

引用

页码：37 / 39

页数：3

共 14 条

[1] Fever increases the risk for cardiac arrest in the Brugada syndrome [J].

Amin, Ahmad S. ;

Meregalli, Paola G. ;

Bardai, Abdennasser ;

Wilde, Arthur A. M. ;

Tan, Hanno L. .

ANNALS OF INTERNAL MEDICINE, 2008, 149 (03) :216-218

[2] Brugada syndrome - Report of the second consensus conference - Endorsed by the Heart Rhythm Society and the European Heart Rhythm Association [J].

Antzelevitch, C ;

Brugada, P ;

Borggrefe, M ;

Brugada, J ;

Brugada, R ;

Corrado, D ;

Gussak, I ;

LeMarec, H ;

Nademanee, K ;

Riera, ARP ;

Shimizu, W ;

Schulze-Bahr, E ;

Tan, H ;

Wilde, A .

CIRCULATION, 2005, 111 (05) :659-670

[3] Brugada syndrome [J].

Antzelevitch, Charles .

PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, 2006, 29 (10) :1130-1159

[4] The syndrome of right bundle branch block ST segment elevation in V1 to V3 and sudden death -: the Brugada syndrome [J].

Brugada, J ;

Brugada, P ;

Brugada, R .

EUROPACE, 1999, 1 (03) :156-166

[5] Pharmacological and device approach to therapy of inherited cardiac diseases associated with cardiac arrhythmias and sudden death [J].

Brugada, J ;

Brugada, R ;

Brugada, P .

JOURNAL OF ELECTROCARDIOLOGY, 2000, 33 :41-47

[6]

Brugada P, 2005, ARCH MAL COEUR VAISS, V98, P115

[7] RIGHT BUNDLE-BRANCH BLOCK, PERSISTENT ST SEGMENT ELEVATION AND SUDDEN CARDIAC DEATH - A DISTINCT CLINICAL AND ELECTROCARDIOGRAPHIC SYNDROME - A MULTICENTER REPORT [J].

BRUGADA, P ;

BRUGADA, J .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1992, 20 (06) :1391-1396

[8] The full stomach test as a novel diagnostic technique for identifying patients at risk of Brugada syndrome [J].

Ikeda, Takanori ;

Abe, Atsuko ;

Yusu, Satoru ;

Nakamura, Kentaro ;

Ishiguro, Haruhisa ;

Mera, Hisaaki ;

Yotsukura, Masayuki ;

Yoshino, Hideaki .

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 2006, 17 (06) :602-607

[9] Brugada syndrome and fever:: Genetic and molecular characterization of patients carrying SCN5A mutations [J].

Keller, DI ;

Rougier, JS ;

Kucera, JP ;

Benammar, N ;

Fressart, W ;

Guicheney, P ;

Madle, A ;

Frorner, M ;

Schläpfer, J ;

Abriel, H .

CARDIOVASCULAR RESEARCH, 2005, 67 (03) :510-519

[10]

Marquez Manlio F., 2005, Current Drug Targets - Cardiovascular & Haematological Disorders, V5, P409, DOI 10.2174/156800605774370353

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