Megastigmane glycosides from leaves of Eucommia ulmoides Oliver with ACE inhibitory activity

被引：25

作者：

Yan, Jian-Kun ^{[1
,3
]}

Ding, Li-Qin ^{[3
]}

Shi, Xu-Liu ^{[2
,3
]}

Donkor, Paul Owusu ^{[2
,3
]}

Chen, Li-Xia ^{[1
]}

Qiu, Feng ^{[1
,2
,3
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Key Lab Struct Based Drug Design & Discovery, Dept Nat Prod Chem,Minist Educ, Shenyang 110016, Peoples R China

[2] Tianjin Univ Tradit Chinese Med, Sch Chinese Mat Med, Tianjin 300193, Peoples R China

[3] Tianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, Tianjin 300193, Peoples R China

来源：

FITOTERAPIA | 2017年 / 116卷

基金：

美国国家科学基金会;

关键词：

Leaves of Eucommia ulmoides Oliver; Megastigmane glycosides; Eucomegastigsides; Angiotensin converting enzyme (ACE);

D O I：

10.1016/j.fitote.2016.12.001

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four new megastigmane glycosides, eucomegastigsides A-D (2, 3, 5 and 7), together with three known megastigmane glycosides, (6R, 7E, 9R)-9-hydroxy-4, 7-megastigmadien-3-one-9-O-[alpha-L-arabinopyranosyl-(1 -> 6)-beta-D-glucopyranoside (1), foliasalaciosidegi B-1 (4) and eleganoside A (6), were isolated from the leaves of Eucommia ulmoides Oliver. Their anti-hypertensive effect was investigated in vitro based on the inhibition of Angiotensin Converting Enzyme (ACE) using HPLC. The results showed that the isolates (2, 3, 4, 5, 7) had moderate inhibitory effects on ACE in vitro compared with captopril. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：121 / 125

页数：5

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