Synthesis and Characterization of a New Series of Hydroxy Pyrazolines

被引：6
作者：
Parveen, Humaira [1 ]
Iqbal, Prince Firdoos [1 ]
Azam, Amir [1 ]
机构：
[1] Jamia Millia Islamia, Dept Chem, New Delhi 110025, India
来源：
SYNTHETIC COMMUNICATIONS | 2008年 / 38卷 / 22期
关键词：
Chalcone; chalcone dibromide; hydroxy pyrazoline; pyrazoline;
D O I：
10.1080/00397910802241407
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one obtained by Claisen-Schmidt condensation of 2-acetyl thiophene with benzaldehyde was converted into 2,3-dibromo-3-phenyl-1-(thiophen-2-yl)propan-1-one, which on treatment with various thiosemicarbazides in the presence of triethylamine in absolute ethanol, yielded the corresponding hydroxy pyrazolines 3a-h. All the compounds were characterized by IR, (1)H NMR, and (13)C NMR spectra.
引用
收藏
页码：3973 / 3983
页数：11
相关论文
共 12 条
  • [1] Synthesis and DP-IV inhibition of cyano-pyrazoline derivatives as potent anti-diabetic agents
    Ahn, JH
    Kim, HM
    Jung, SH
    Kang, SK
    Kim, KR
    Rhee, SD
    Yang, SD
    Cheon, HG
    Kim, SS
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (17) : 4461 - 4465
  • [2] Synthesis and anti-inflammatory activity of 1-acetyl-5-substitute daryl-3-(β-aminonapthyl)-2-pyrazolines and β-(substituted aminoethyl) amidonaphthalenes
    Bansal, E
    Srivastava, VK
    Kumar, A
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2001, 36 (01) : 81 - 92
  • [3] Synthesis and antiamoebic activity of new 1-N-substituted thiocarbamoyl-3,5-diphenyl-2-pyrazoline derivatives and their Pd(II) complexes
    Budakoti, A
    Abid, M
    Azam, A
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2006, 41 (01) : 63 - 70
  • [4] Elguero J., 1997, COMPREHENSIVE HETERO, V5, P167, DOI DOI 10.1016/B978-008096519-2.00072-2
  • [5]
    [Z].
  • [6] Fan W.-Q., 1996, COMPREHENSIVE HETERO, V4, P1, DOI DOI 10.1016/B978-008096518-5.00059-9
  • [7] Holla BS, 2000, FARMACO, V55, P256
  • [8] Synthesis and antimicrobial studies on novel chloro-fluorine containing hydroxy pyrazolines
    Karthikeyan, Mari Sithambaram
    Holla, Bantwal Shivarama
    Kumari, Nalilu Suchetha
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2007, 42 (01) : 30 - 36
  • [9] Synthesis of some pyrazole derivatives and preliminary investigation of their affinity binding to P-glycoprotein
    Manna, F
    Chimenti, F
    Fioravanti, R
    Bolasco, A
    Secci, D
    Chimenti, P
    Ferlini, C
    Scambia, G
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (20) : 4632 - 4635
  • [10] Synthesis and antidepressant activity of some 1,3,5-triphenyl-2-pyrazolines and 3-(2"-hydroxy naphthalen-1"-yl)-1,5-diphenyl-2-pyrazolines
    Prasad, YR
    Rao, AL
    Prasoona, L
    Murali, K
    Kumar, PR
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (22) : 5030 - 5034
12