Trichotillomania: A Case of Response to Valproic Acid

被引:10
作者
Adewuya, Edore C. [1 ]
Zinser, William [2 ]
Thomas, Christopher [1 ]
机构
[1] Univ Texas Galveston, Med Branch, Dept Psychiat & Behav Sci, Div Child & Adolescent Psychiat, Galveston, TX 77555 USA
[2] Univ Texas SW Med Ctr Dallas, Dept Pediat Neurol, Dallas, TX 75390 USA
关键词
D O I
10.1089/cap.2008.076
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Trichotillomania (TTM) is a commonly undiagnosed psychiatric illness with known medical complications whose symptoms interfere markedly with daily functioning. Studies regarding the pharmacological treatment of TTM in the adult or pediatric population are sparse, and there is a lack of consensus on drug treatment for TTM. The current trend is to use selective serotonin reuptake inhibitors (SSRIs) on the basis of the current hypothesis that TTM may be a part of the obsessive compulsive spectrum of disorders. However, attempts to substantiate the efficacy of SSRI use in TTM has produced conflicting results. There is increasing evidence that mood stabilizers decrease symptoms of TTM. We present the case of a 10-year-old girl whose lifelong hairplucking symptoms showed remarkable sustained improvement in response to increased levels of valproic acid. This report, the first with valproic acid, indicates that this drug is potentially effective in significantly reducing symptoms of TTM in a sustained manner. This single case report calls for further investigation regarding the utility of valproic acid in the treatment of TTM.
引用
收藏
页码:533 / 536
页数:4
相关论文
共 38 条
[1]  
*AM PSYCH ASS, 2006, AM PSYCH ASS PRACT G, P185
[2]   HABIT-REVERSAL - METHOD OF ELIMINATING NERVOUS HABITS AND TICS [J].
AZRIN, NH ;
NUNN, RG .
BEHAVIOUR RESEARCH AND THERAPY, 1973, 11 (04) :619-628
[3]   TREATMENT OF HAIRPULLING (TRICHOTILLOMANIA) - A COMPARATIVE-STUDY OF HABIT REVERSAL AND NEGATIVE PRACTICE TRAINING [J].
AZRIN, NH ;
NUNN, RG ;
FRANTZ, SE .
JOURNAL OF BEHAVIOR THERAPY AND EXPERIMENTAL PSYCHIATRY, 1980, 11 (01) :13-20
[4]   Trichotillomania: response to lithium in a person with comorbid bipolar disorder [J].
Berk, M ;
McKenzie, H ;
Dodd, S .
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL, 2003, 18 (07) :576-577
[5]   Systematic review: Pharmacological and Behavioral treatment for trichotillomania [J].
Bloch, Michael H. ;
Landeros-Weisenberger, Angeli ;
Dombrowski, Philip ;
Kelmendi, Ben ;
Wegner, Ryan ;
Nudel, Jake ;
Pittenger, Christopher ;
Leckman, James F. ;
Coric, Vladimir .
BIOLOGICAL PSYCHIATRY, 2007, 62 (08) :839-846
[6]  
CHRISTENSON GA, 1991, AM J PSYCHIAT, V148, P1566
[7]  
CHRISTENSON GA, 1992, J CLIN PSYCHIAT, V53, P407
[8]  
CHRISTENSON GA, 1991, AM J PSYCHIAT, V148, P365
[9]  
CHRISTENSON GA, 1991, J CLIN PSYCHIAT, V52, P415
[10]  
CHRISTENSON GA, 1991, J CLIN PSYCHIAT, V52, P116