Fast capillary electrophoresis coupled with time-of-flight mass spectrometry under separation conditions of high electrical field strengths

被引:15
作者
Matysik, Frank-Michael [1 ]
Neusuess, Christian [2 ]
Pelzing, Matthias [3 ]
机构
[1] Univ Regensburg, Inst Analyt Chem Chemo & Biosensors, Regensburg, Germany
[2] Hsch Aalen, Aalen, Germany
[3] Bruker Biosci, Melbourne, Vic, Australia
关键词
D O I
10.1039/b806349d
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
An experimental approach is presented that enables very fast capillary electrophoretic separations in conjunction with time-of-flight mass spectrometry. Field strengths exceeding 1 kV cm(-1) have been applied for separations of model analytes resulting in migration times on the timescale of seconds.
引用
收藏
页码:1764 / 1766
页数:3
相关论文
共 19 条
[1]   Top-down analysis of basic proteins by microchip capillary electrophoresis mass spectrometry [J].
Akashi, Satoko ;
Suzuki, Koichi ;
Arai, Akihiro ;
Yamada, Naoyuki ;
Suzuki, Ei-Ichiro ;
Hirayama, Kazuo ;
Nakamura, Shin ;
Nishimura, Yoshifumi .
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2006, 20 (12) :1932-1938
[2]   Miniaturized capillary electrophoresis system with a carbon nanotube microelectrode for rapid separation and detection of thiols [J].
Chen, G ;
Zhang, LY ;
Wang, J .
TALANTA, 2004, 64 (04) :1018-1023
[3]   On-line capillary electrophoresis-mass spectrometry for the analysis of biomolecules [J].
Hernández-Borges, J ;
Neusüss, C ;
Cifuentes, A ;
Pelzing, M .
ELECTROPHORESIS, 2004, 25 (14) :2257-2281
[4]   FAST, HIGH-RESOLUTION (CAPILLARY) ELECTROPHORESIS IN BUFFERS DESIGNED FOR HIGH-FIELD STRENGTHS [J].
HJERTEN, S ;
VALTCHEVA, L ;
ELENBRING, K ;
LIAO, JL .
ELECTROPHORESIS, 1995, 16 (04) :584-594
[5]   Microfluidic glass chips with an integrated nanospray emitter for coupling to a mass spectrometer [J].
Hoffmann, Peter ;
Haeusig, Ulrich ;
Schulze, Philipp ;
Belder, Detlev .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, 46 (26) :4913-4916
[6]   Separation of hyaluronic acid by ultrahigh-voltage capillary gel electrophoresis [J].
Hutterer, KM ;
Jorgenson, JW .
ELECTROPHORESIS, 2005, 26 (10) :2027-2033
[7]   Ultrahigh-voltage capillary zone electrophoresis [J].
Hutterer, KM ;
Jorgenson, JW .
ANALYTICAL CHEMISTRY, 1999, 71 (07) :1293-1297
[8]   Scaling and the design of miniaturized chemical-analysis systems [J].
Janasek, Dirk ;
Franzke, Joachim ;
Manz, Andreas .
NATURE, 2006, 442 (7101) :374-380
[9]   Recent advances in the application of capillary electrophoresis with mass spectrometric detection [J].
Klampfl, CW .
ELECTROPHORESIS, 2006, 27 (01) :3-34
[10]   Microfluidic devices for environmental monitoring [J].
Marle, L ;
Greenway, GM .
TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2005, 24 (09) :795-802