Strategies to Direct Angiogenesis within Scaffolds for Bone Tissue Engineering

被引：26

作者：

Harris, Greg M. ^{[1
]}

Rutledge, Katy ^{[1
]}

Cheng, Qingsu ^{[2
]}

Blanchette, James ^{[1
,2
]}

Jabbarzadeh, Ehsan ^{[1
,2
,3
]}

机构：

[1] Univ S Carolina, Dept Chem Engn, Columbia, SC 29208 USA

[2] Univ S Carolina, Biomed Engn Program, Columbia, SC 29208 USA

[3] Univ S Carolina, Dept Orthopaed Surg, Columbia, SC 29208 USA

来源：

CURRENT PHARMACEUTICAL DESIGN | 2013年 / 19卷 / 19期

关键词：

Angiogenesis; tissue engineering; bone; scaffold; microscale patterning; growth factor delivery; cell transplantation; ENDOTHELIAL GROWTH-FACTOR; MESENCHYMAL STEM-CELLS; HYPOXIA-INDUCIBLE FACTOR-1; CIRCULATING PROGENITOR CELLS; IN-VITRO ANGIOGENESIS; FACTOR DELIVERY; BLOOD-VESSELS; GENE-THERAPY; POSTNATAL NEOVASCULARIZATION; EXTRACELLULAR-MATRIX;

D O I：

10.2174/1381612811319190011

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

There is a profound need for orthopaedic grafting strategies due to various trauma and musculoskeletal diseases. Tissue engineering offers a promising avenue to develop viable grafts for bone repair. The transfer of bone tissue engineering strategies to clinical applications is limited by the failure to adequately vascularize scaffolds after implantation. This review focuses on the natural processes for bone and vessel formation as well as the microenvironmental cues and microscale fabrication techniques to properly coordinate these events towards successful vascularization of tissue engineered scaffolds.

引用

页码：3456 / 3465

页数：10

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