The role of BCS (biopharmaceutics classification system) and BDDCS (biopharmaceutics drug disposition classification system) in drug development

被引：233

作者：

Benet, Leslie Z. ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, Sch Pharm, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Sch Med, San Francisco, CA 94143 USA

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 2013年 / 102卷 / 01期

关键词：

BCS; BDDCS; drug development; permeability; metabolism; solubility; brain distribution; IN-VITRO; HYDROXY METABOLITES; HEPATIC-UPTAKE; UREMIC TOXINS; PREDICTION; ATORVASTATIN; PHARMACOKINETICS; PERMEABILITY; TRANSPORTERS; INTERPLAY;

D O I：

10.1002/jps.23359

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Biopharmaceutics Classification System and Biopharmaceutics Drug Distribution Classification System are complimentary, not competing, classification systems that aim to improve, simplify, and speed drug development. Although both systems are based on classifying drugs and new molecular entities into four categories using the same solubility criteria, they differ in the criterion for permeability and have different purposes. Here, the details and applications of both systems are reviewed with particular emphasis of their role in drug development. (c) 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 102:3442, 2013

引用

页码：34 / 42

页数：9

共 40 条

[1] A THEORETICAL BASIS FOR A BIOPHARMACEUTIC DRUG CLASSIFICATION - THE CORRELATION OF IN-VITRO DRUG PRODUCT DISSOLUTION AND IN-VIVO BIOAVAILABILITY [J].