Effects of warfarin on biological processes other than haemostasis: A review

被引：21

作者：

Aleksandrov, Aleksandra Popov ^{[1
]}

Mirkov, Ivana ^{[1
]}

Ninkov, Marina ^{[1
]}

Mileusnic, Dina ^{[1
]}

Demenesku, Jelena ^{[1
]}

Subota, Vesna ^{[2
]}

Kataranovski, Dragan ^{[1
,3
]}

Kataranovski, Milena ^{[1
,4
]}

机构：

[1] Univ Belgrade, Inst Biol Res Sinisa Stankovic, Dept Ecol, Immunotoxicol Grp, 192 Bulevar Despota Stefana, Belgrade 11000, Serbia

[2] Mil Med Acad, Inst Med Biochem, 17 Crnotrayska, Belgrade 11000, Serbia

[3] Univ Belgrade, Fac Biol, Inst Zool, 16 Studentski Trg, Belgrade 11000, Serbia

[4] Univ Belgrade, Fac Biol, Inst Physiol & Biochem, 16 Studentski Trg, Belgrade 11000, Serbia

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2018年 / 113卷

关键词：

Warfarin; Bone growth; Vascular calcification; Anti-tumour effects; Immunomodulatory/inflammatory effects; ANTICOAGULANT RODENTICIDE WARFARIN; VITAMIN-K-ANTAGONISTS; ARREST-SPECIFIC GENE-6; CELL LUNG-CANCER; CORONARY-HEART-DISEASE; SMOOTH-MUSCLE-CELLS; ACUTE-RENAL-FAILURE; LOW-DOSE WARFARIN; PROTEIN-S; ORAL WARFARIN;

D O I：

10.1016/j.fct.2018.01.019

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Warfarin is the world's most widely used anticoagulant drug. Its anticoagulant activity is based on the inhibition of the vitamin K-dependent (VKD) step in the complete synthesis of a number of blood coagulation factors that are required for normal blood coagulation. Warfarin also affects synthesis of VKD proteins not related to haemostasis including those involved in bone growth and vascular calcification. Antithrombotic activity of warfarin is considered responsible for some aspects of its anti-tumour activity of warfarin. Some aspects of activities against tumours seem not to be related to haemostasis and included effects of warfarin on non-haemostatic VKD proteins as well as those not related to VIM proteins. Inflammatory/immunomodulatory effects of warfarin indicate much broader potential of action of this drug both in physiological and pathological processes. This review provides an overview of the published data dealing with the effects of warfarin on biological processes other than haemostasis.

引用

页码：19 / 32

页数：14

共 220 条

[1] Protein S drives oral squamous cell carcinoma tumorigenicity through regulation of AXL [J].

Abboud-Jarrous, Ghada ;

Priya, Shivam ;

Maimon, Avi ;

Fischman, Stuart ;

Cohen-Elisha, Mayan ;

Czerninski, Rakefet ;

Burstyn-Cohen, Tal .

ONCOTARGET, 2017, 8 (08) :13986-14002

[2] INTENSIVE COMBINATION CHEMOTHERAPY, CONCURRENT CHEST IRRADIATION, AND WARFARIN FOR THE TREATMENT OF LIMITED-DISEASE SMALL-CELL LUNG-CANCER - A CANCER AND LEUKEMIA GROUP-B PILOT-STUDY [J].

AISNER, J ;

GOUTSOU, M ;

MAURER, LH ;

COOPER, R ;

CHAHINIAN, P ;

CAREY, R ;

SKARIN, A ;

SLAWSON, R ;

PERRY, MC ;

GREEN, MR .

JOURNAL OF CLINICAL ONCOLOGY, 1992, 10 (08) :1230-1236

[3] Proinflammatory cytokine responses in skin and epidermal cells following epicutaneous administration of anticoagulant rodenticide warfarin in rats [J].

Aleksandrov, Aleksandra Popov ;

Tusup, Marina ;

Mirkov, Ivana ;

Djokic, Jelena ;

Ninkov, Marina ;

Zolotarevski, Lidija ;

Kataranovski, Dragan ;

Kataranovski, Milena .

CUTANEOUS AND OCULAR TOXICOLOGY, 2015, 34 (02) :149-155

[4]

Amini S, 2013, IRAN J PHARM RES, V12, P945

[5] Serum-derived protein S binds to phosphatidylserine and stimulates the phagocytosis of apoptotic cells [J].

Anderson, HA ;

Maylock, CA ;

Williams, JA ;

Paweletz, CP ;

Shu, HJ ;

Shacter, E .

NATURE IMMUNOLOGY, 2003, 4 (01) :87-91

[6] Association mechanism between a series of rodenticide and humic acid:: A frontal analysis to support the biological data [J].

André, C ;

Guyon, C ;

Thomassin, M ;

Barbier, A ;

Richert, L ;

Guillaume, YC .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2005, 820 (01) :9-14

[7]

[Anonymous], 1995, Environmental Health Critaric 2a, P1

[8] AKI Associated with Macroscopic Glomerular Hematuria: Clinical and Pathophysiologic Consequences [J].

Antonio Moreno, Juan ;

Martin-Cleary, Catalina ;

Gutierrez, Eduardo ;

Toldos, Oscar ;

Miguel Blanco-Colio, Luis ;

Praga, Manuel ;

Ortiz, Alberto ;

Egido, Jesus .

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2012, 7 (01) :175-184

[9] Role of growth arrest-specific gene 6 in diabetic nephropathy [J].

Arai, Hidenori ;

Nagai, Kojiro ;

Doi, Toshio .

VITAMIN K, 2008, 78 :375-392

[10] Analysis of Gas6 in human platelets and plasma [J].

Balogh, I ;

Hafizi, S ;

Stenhoff, J ;

Hansson, K ;

Dahlbäck, B .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2005, 25 (06) :1280-1286

← 1 2 3 4 5 6 7 8 9 10 →