Novel therapeutics in myocardial infarction: targeting microvascular dysfunction and reperfusion injury

被引：57
作者：
Fordyce, Christopher B. [1 ]
Gersh, Bernard J. [2 ]
Stone, Gregg W. [3 ,4 ]
Granger, Christopher B. [1 ]
机构：
[1] Duke Clin Res Inst, Durham, NC 27705 USA
[2] Mayo Clin, Coll Med, Div Cardiovasc Med, Rochester, MN USA
[3] Columbia Univ, Med Ctr, New York Presbyterian Hosp, New York, NY USA
[4] Cardiovasc Res Fdn, New York, NY USA
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 2015年 / 36卷 / 09期
关键词：
myocardial infarction; reperfusion injury; coronary microcirculation; novel therapeutics; PERCUTANEOUS CORONARY INTERVENTION; NO-REFLOW PHENOMENON; TO-BALLOON TIME; DOSE INTRACORONARY ADENOSINE; RANDOMIZED CONTROLLED-TRIAL; GLUCOSE-INSULIN-POTASSIUM; IMPROVES CARDIAC-FUNCTION; PLACEBO-CONTROLLED TRIAL; THROMBUS ASPIRATION; PRIMARY ANGIOPLASTY;
D O I：
10.1016/j.tips.2015.06.004
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Despite the large number of novel therapies under basic scientific investigation, the translation of cardioprotective strategies targeting repel-fusion injury to improve patient outcomes following percutaneous coronary intervention (PCI) for myocardial infarction (MI) has been disappointing. The varying susceptibility of an individual to reperfusion injury, as well as the narrow window of opportunity in which to intervene, adds significant complexity. Here, we discuss the unmet need and challenges of translating cardioprotective strategies into clinical practice, review the pathophysiology of microvascular dysfunction and lethal reperfusion as they relate to promising novel therapeutics, and evaluate recent and ongoing clinical trials in the field.
引用
收藏
页码：605 / 616
页数：12
相关论文
共 137 条
  • [51] Headrick John P, 2009, Handb Exp Pharmacol, P189, DOI 10.1007/978-3-540-89615-9_7
  • [52] Infarct evolution in man studied in patients with first-time coronary occlusion in comparison to different species - implications for assessment of myocardial salvage
    Hedstrom, Erik
    Engblom, Henrik
    Frogner, Fredrik
    Astrom-Olsson, Karin
    Ohlin, Hans
    Jovinge, Stefan
    Arheden, Hakan
    [J]. JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, 2009, 11
  • [53] Remote Ischemic Conditioning
    Heusch, Gerd
    Botker, Hans Erik
    Przyklenk, Karin
    Redington, Andrew
    Yellon, Derek
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2015, 65 (02) : 177 - 195
  • [54] DETermination of the role of OXygen in suspected Acute Myocardial Infarction trial
    Hofmann, Robin
    James, Stefan K.
    Svensson, Leif
    Witt, Nils
    Frick, Mats
    Lindahl, Bertil
    Ostlund, Ollie
    Ekelund, Ulf
    Erlinge, David
    Herlitz, Johan
    Jernberg, Tomas
    [J]. AMERICAN HEART JOURNAL, 2014, 167 (03) : 322 - 328
  • [55] Sequelae of acute myocardial infarction regarding cardiac structure and function and their prognostic significance as assessed by magnetic resonance imaging
    Hombach, V
    Grebe, O
    Merkle, N
    Waldenmaier, S
    Höher, M
    Kochs, M
    Wöhrle, J
    Kestler, HA
    [J]. EUROPEAN HEART JOURNAL, 2005, 26 (06) : 549 - 557
  • [56] Clinical implications of the 'no reflow' phenomenon - A predictor of complications and left ventricular remodeling in reperfused anterior wall myocardial infarction
    Ito, H
    Maruyama, A
    Iwakura, K
    Takiuchi, S
    Masuyama, T
    Hori, M
    Higashino, Y
    Fujii, K
    Minamino, T
    [J]. CIRCULATION, 1996, 93 (02) : 223 - 228
  • [57] No-reflow phenomenon and prognosis in patients with acute myocardial infarction
    Ito, Hiroshi
    [J]. NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE, 2006, 3 (09): : 499 - 506
  • [58] Randomized Trial of Primary PCI with or without Routine Manual Thrombectomy
    Jolly, S. S.
    Cairns, J. A.
    Yusuf, S.
    Meeks, B.
    Pogue, J.
    Rokoss, M. J.
    Kedev, S.
    Thabane, L.
    Stankovic, G.
    Moreno, R.
    Gershlick, A.
    Chowdhary, S.
    Lavi, S.
    Niemela, K.
    Steg, P. G.
    Bernat, I.
    Xu, Y.
    Cantor, W. J.
    Overgaard, C. B.
    Naber, C. K.
    Cheema, A. N.
    Welsh, R. C.
    Bertrand, O. F.
    Avezum, A.
    Bhindi, R.
    Pancholy, S.
    Rao, S. V.
    Natarajan, M. K.
    ten Berg, J. M.
    Shestakovska, O.
    Gao, P.
    Widimsky, P.
    Dzavik, V.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (15) : 1389 - 1398
  • [59] The safety and efficacy of intracoronary nitrite infusion during acute myocardial infarction (NITRITE-AMI): study protocol of a randomised controlled trial
    Jones, D. A.
    Andiapen, M.
    Van-Eijl, T. J. A.
    Webb, A. J.
    Antoniou, S.
    Schilling, R. J.
    Ahluwalia, A.
    Mathur, A.
    [J]. BMJ OPEN, 2013, 3 (04):
  • [60] Identification of preoperative variables needed for risk adjustment of short-term mortality after coronary artery bypass graft surgery
    Jones, RH
    Hannan, EL
    Hammermeister, KE
    DeLong, ER
    OConnor, GT
    Luepker, RV
    Parsonnet, V
    Pryor, DB
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1996, 28 (06) : 1478 - 1487
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