Synthesis and Antifungal Activity of 3-Substituted-thiochroman-4-one Semicarbazone Derivatives

被引：9

作者：

Geng, Hong-jian ^{[1
]}

Xing, Zhao-bin ^{[1
]}

Luo, Wei ^{[1
]}

Cong, Ling ^{[1
]}

Li, Xin-yu ^{[1
]}

Guo, Chun ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Peoples R China

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2012年 / 9卷 / 08期

关键词：

3-substituted-thiochroman-4-one semicarbazone; Synthesis; Antifungal activity; BIOLOGICAL EVALUATION;

D O I：

10.2174/157018012802652903

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 3-substituted-thiochroman-4-one semicarbazone derivatives were designed based on the bioisosterism and combination principle in drug design. The target compounds were prepared from 3-substituted-thiochroman-4-one (1) and 4-substituted-semicarbazides(2), their structures were confirmed by MS and H-1 NMR. The antifungal assay was carried out in vitro by twofold dilution. The result shows that all the compounds are of antifungal activities against the tested fungi at different levels.

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页码：797 / 801

页数：5

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