Concepts of metastasis in flux: The stromal progression model

被引:70
作者
Sleeman, Jonathan P. [1 ]
Christofori, Gerhard [2 ]
Fodde, Riccardo [3 ]
Collard, John G. [4 ]
Berx, Geert [5 ,6 ]
Decraene, Charles [7 ,8 ]
Rueegg, Curzio [9 ]
机构
[1] Heidelberg Univ, Univ Med Mannheim, Ctr Biomed & Med Technol Mannheim CBTM, D-68167 Mannheim, Germany
[2] Univ Basel, Inst Biochem & Genet, Dept Biomed, CH-4058 Basel, Switzerland
[3] Erasmus MC, Josephine Netkens Inst, Dept Pathol, Rotterdam, Netherlands
[4] Netherlands Canc Inst, Div Cell Biol, NL-1066 CX Amsterdam, Netherlands
[5] Univ Ghent VIB, Dept Mol Biomed Res, Unit Mol & Cellular Oncol, B-9052 Ghent, Belgium
[6] Univ Ghent, Dept Biomed Biol, B-9052 Ghent, Belgium
[7] Inst Curie, Translat Res Dept, Ctr Rech, Paris, France
[8] CNRS, UMR144, Paris, France
[9] Univ Fribourg, Dept Med, Fac Sci, CH-1700 Fribourg, Switzerland
关键词
Metastasis; Seed and soil; Clonal selection; Parallel progression; EMT; Cancer stem cell; Metastatic niche; Microenvironment; Stromal progression; EPITHELIAL-MESENCHYMAL TRANSITION; CIRCULATING TUMOR-CELLS; CANCER STEM-CELLS; BREAST-CANCER; TGF-BETA; CARCINOMA-CELLS; BONE-MARROW; LYMPH-NODE; E-CADHERIN; COLORECTAL-CANCER;
D O I
10.1016/j.semcancer.2012.02.007
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The ability of tumor cells to leave a primary tumor, to disseminate through the body, and to ultimately seed new secondary tumors is universally agreed to be the basis for metastasis formation. An accurate description of the cellular and molecular mechanisms that underlie this multistep process would greatly facilitate the rational development of therapies that effectively allow metastatic disease to be controlled and treated. A number of disparate and sometimes conflicting hypotheses and models have been suggested to explain various aspects of the process, and no single concept explains the mechanism of metastasis in its entirety or encompasses all observations and experimental findings. The exciting progress made in metastasis research in recent years has refined existing ideas, as well as giving rise to new ones. In this review we survey some of the main theories that currently exist in the field, and show that significant convergence is emerging, allowing a synthesis of several models to give a more comprehensive overview of the process of metastasis. As a result we postulate a stromal progression model of metastasis. In this model, progressive modification of the tumor microenvironment is equally as important as genetic and epigenetic changes in tumor cells during primary tumor progression. Mutual regulatory interactions between stroma and tumor cells modify the stemness of the cells that drive tumor growth, in a manner that involves epithelial-mesenchymal and mesenchymal-epithelial-like transitions. Similar interactions need to be recapitulated at secondary sites for metastases to grow. Early disseminating tumor cells can progress at the secondary site in parallel to the primary tumor, both in terms of genetic changes, as well as progressive development of a metastatic stroma. Although this model brings together many ideas in the field, there remain nevertheless a number of major open questions, underscoring the need for further research to fully understand metastasis, and thereby identify new and effective ways of treating metastatic disease. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码:174 / 186
页数:13
相关论文
共 50 条
[31]   Aurora-A Regulates Progression and Metastasis of Colorectal Cancer by Promoting Slug Activity [J].
He, Jin-Guang ;
Li, Luming ;
Qin, Ying ;
Yu, Wenfei ;
He, Xiuquan ;
Gang, Ren .
TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 2017, 16 (06) :766-775
[32]   From LncRNA to metastasis: The MALAT1-EMT axis in cancer progression [J].
Thapa, Riya ;
Afzal, Obaid ;
Afzal, Muhammad ;
Gupta, Gaurav ;
Bhat, Asif Ahmad ;
Almalki, Waleed Hassan ;
Kazmi, Imran ;
Alzarea, Sami I. ;
Saleem, Shakir ;
Arora, Poonam ;
Singh, Sachin Kumar ;
Dua, Kamal .
PATHOLOGY RESEARCH AND PRACTICE, 2024, 253
[33]   TGF-β and BMP7 interactions in tumour progression and bone metastasis [J].
Buijs, Jeroen T. ;
Henriquez, Niek V. ;
van Overveld, Petra G. M. ;
van der Horst, Geertje ;
ten Dijke, Peter ;
van der Pluijm, Gabri .
CLINICAL & EXPERIMENTAL METASTASIS, 2007, 24 (08) :609-617
[34]   The role of hypoxia on prostate cancer progression and metastasis [J].
Mohamed, Osama A. A. ;
Tesen, Heba S. ;
Hany, Marwa ;
Sherif, Aya ;
Abdelwahab, Maya Magdy ;
Elnaggar, Muhammed H. .
MOLECULAR BIOLOGY REPORTS, 2023, 50 (04) :3873-3884
[35]   Role of MicroRNAs in the Progression and Metastasis of Colon Cancer [J].
Sampath, Shruthi Sanjitha ;
Venkatabalasubramanian, Sivaramakrishnan ;
Ramalingam, Satish .
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS, 2021, 21 (01) :35-46
[36]   TAMeless traitors: macrophages in cancer progression and metastasis [J].
Aras, Shweta ;
Zaidi, M. Raza .
BRITISH JOURNAL OF CANCER, 2017, 117 (11) :1583-1591
[37]   Bacterial Involvement in Progression and Metastasis of Adenocarcinoma of the Stomach [J].
Morgan, Amanda D. ;
Seely, Kevin D. ;
Hagenstein, Lauren D. ;
Florey, Garrett M. ;
Small, James M. .
CANCERS, 2022, 14 (19)
[38]   Intravital imaging to study cancer progression and metastasis [J].
Entenberg, David ;
Oktayt, Maja H. ;
Condeelis, John S. .
NATURE REVIEWS CANCER, 2023, 23 (01) :25-42
[39]   Therapeutic potential of mesenchymal stromal cells in a mouse breast cancer metastasis model [J].
Sun, Bo ;
Roh, Kyoung-Hwan ;
Park, Jeong-Ran ;
Lee, Sae-Rom ;
Park, Sang-Bum ;
Jung, Ji-Won ;
Kang, Soo-Kyung ;
Lee, Yong-Soon ;
Kang, Kyung-Sun .
CYTOTHERAPY, 2009, 11 (03) :289-U14
[40]   Cancer-associated fibroblasts: a versatile mediator in tumor progression, metastasis, and targeted therapy [J].
Guo, Tianchen ;
Xu, Junfen .
CANCER AND METASTASIS REVIEWS, 2024, 43 (03) :1095-1116