Purine salvage in Leishmania: complex or simple by design?

被引：68

作者：

Boitz, Jan M. ^{[1
]}

Ullman, Buddy ^{[1
]}

Jardim, Armando ^{[2
]}

Carter, Nicola S. ^{[1
]}

机构：

[1] Oregon Hlth & Sci Univ, Dept Biochem & Mol Biol, Portland, OR 97239 USA

[2] McGill Univ, Inst Parasitol, Ste Anne De Bellevue, PQ H9X 3V9, Canada

来源：

TRENDS IN PARASITOLOGY | 2012年 / 28卷 / 08期

基金：

美国国家卫生研究院;

关键词：

HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE; MEMBRANE 3'-NUCLEOTIDASE NUCLEASE; INOSINE-GUANOSINE TRANSPORTER; SURFACE-MEMBRANE; ADENINE PHOSPHORIBOSYLTRANSFERASE; XANTHINE PHOSPHORIBOSYLTRANSFERASE; NUCLEOBASE TRANSPORTER; NUCLEOSIDE HYDROLASE; STABLE TRANSFECTION; ACID-PHOSPHATASE;

D O I：

10.1016/j.pt.2012.05.005

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Purine nucleotides function in a variety of vital cellular and metabolic processes including energy production, cell signaling, synthesis of vitamin-derived cofactors and nucleic acids, and as determinants of cell fate. Unlike their mammalian and insect hosts, Leishmania cannot synthesize the purine ring de nova and are absolutely dependent upon them to meet their purine requirements. The obligatory nature of purine salvage in these parasites, therefore, offers an attractive paradigm for drug targeting and, consequently, the delineation of the pathway has been under scientific investigation for over 30 years. Here, we review recent developments that reveal how purines flux in Leishmania and offer a potential 'Achilles' heel' for future validation.

引用

页码：345 / 352

页数：8

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