Phenyl Hydrazine as Initiator for Direct Arene C-H Arylation via Base Promoted Homolytic Aromatic Substitution

被引：110
作者：
Dewanji, Abhishek
Murarka, Sandip
Curran, Dennis P.
Studer, Armido
机构：
[1] Univ Munster, NRW Grad Sch Chem, Inst Organ Chem, D-48149 Munster, Germany
[2] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA
来源：
ORGANIC LETTERS | 2013年 / 15卷 / 23期
关键词：
ARYL BOND FORMATION; UNACTIVATED ARENES; BUTOXIDE; HALIDES; ACTIVATION; BENZENE;
D O I：
10.1021/ol402995e
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and efficient direct radical arylation of unactivated arenes is described which uses cheap and commercially available phenyl hydrazine as an initiator. The reaction occurs through a base promoted homolytic aromatic substitution (BHAS) mechanism involving aryl radicals and aryl radical anions as intermediates and offers a practical approach for preparation of an array of substituted biaryls.
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收藏
页码：6102 / 6105
页数：4
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