Herpesvirus-encoded GPCRs: neglected players in inflammatory and proliferative diseases?

被引：75
作者：
Vischer, Henry F. [1 ]
Siderius, Marco [1 ]
Leurs, Rob [1 ]
Smit, Martine J. [1 ]
机构：
[1] Vrije Univ Amsterdam, Fac Sci, Amsterdam Inst Mol Med & Syst, Div Med Chem, NL-1081 HV Amsterdam, Netherlands
来源：
NATURE REVIEWS DRUG DISCOVERY | 2014年 / 13卷 / 02期
关键词：
PROTEIN-COUPLED RECEPTOR; SARCOMA-ASSOCIATED-HERPESVIRUS; EPSTEIN-BARR-VIRUS; NF-KAPPA-B; PRIMARY-EFFUSION LYMPHOMA; CYTOMEGALOVIRUS US28 PROTEIN; GROWTH-FACTOR RECEPTOR; MUSCLE-CELL MIGRATION; KAPOSIS-SARCOMA; CHEMOKINE-RECEPTOR;
D O I：
10.1038/nrd4189
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Herpesviruses encode membrane-associated G protein-coupled receptors (GPCRs) in their viral genomes that are structurally similar to chemokine receptors. These GPCRs hijack GPCR-mediated cellular signalling networks of the host for survival, replication and pathogenesis. In particular the herpesvirus-encoded chemokine receptors ORF74, BILF1 and US28, which are present at inflammatory sites and tumour cells, provide important virus-specific targets for directed therapies. Given the high druggability of GPCRs in general, these viral GPCRs can be considered promising antiviral drug targets.
引用
收藏
页码：123 / 139
页数：17
相关论文
共 189 条
[1]   An androgen-IL-6-Stat3 autocrine loop re-routes EGF signal in prostate cancer cells [J].
Aaronson, David S. ;
Muller, Melissa ;
Neves, Susana R. ;
Chung, Wen-Chen ;
Jayaram, Gomathi ;
Iyengar, Ravi ;
Ram, Prahlad T. .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2007, 270 (1-2) :50-56
[2]  
[Anonymous], 2012, Drug Discov Today Technol, V9, pe227, DOI 10.1016/j.ddtec.2012.05.003
[3]   The US27 gene product of human cytomegalovirus enhances signaling of host chemokine receptor CXCR4 [J].
Arnolds, Kathleen L. ;
Lares, Angela P. ;
Spencer, Juliet V. .
VIROLOGY, 2013, 439 (02) :122-131
[4]   Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation [J].
Arvanitakis, L ;
GerasRaaka, E ;
Varma, A ;
Gershengorn, MC ;
Cesarman, E .
NATURE, 1997, 385 (6614) :347-350
[5]   Kaposi's sarcoma associated herpesvirus G protein-coupled receptor immortalizes human endothelial cells by activation of the VEGF receptor-2/KDR [J].
Bais, C ;
Van Geelen, A ;
Eroles, P ;
Mutlu, A ;
Chiozzini, C ;
Dias, S ;
Silverstein, RL ;
Rafii, S ;
Mesri, EA .
CANCER CELL, 2003, 3 (02) :131-143
[6]   G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator [J].
Bais, C ;
Santomasso, B ;
Coso, O ;
Arvanitakis, L ;
Raaka, EG ;
Gutkind, JS ;
Asch, AS ;
Cesarman, E ;
Gerhengorn, MC ;
Mesri, EA .
NATURE, 1998, 391 (6662) :86-89
[7]   Constitutively active Gq/11-coupled receptors enable signaling by co-expressed Gi/o-coupled receptors [J].
Bakker, RA ;
Casarosa, P ;
Timmerman, H ;
Smit, MJ ;
Leurs, R .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (07) :5152-5161
[8]   Detection of human cytomegalovirus in medulloblastomas reveals a potential therapeutic target [J].
Baryawno, Ninib ;
Rahbar, Afsar ;
Wolmer-Solberg, Nina ;
Taher, Chato ;
Odeberg, Jenny ;
Darabi, Anna ;
Khan, Zahidul ;
Sveinbjornsson, Baldur ;
Fuskevag, O. -M. ;
Segerstrom, Lova ;
Nordenskjold, Magnus ;
Siesjo, Peter ;
Kogner, Per ;
Johnsen, John Inge ;
Soderberg-Naucler, Cecilia .
JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (10) :4043-4055
[9]   The R33 G protein-coupled receptor gene of rat cytomegalovirus plays an essential role in the pathogenesis of viral infection [J].
Beisser, PS ;
Vink, C ;
Van Dam, JG ;
Grauls, G ;
Vanherle, SJV ;
Bruggeman, CA .
JOURNAL OF VIROLOGY, 1998, 72 (03) :2352-2363
[10]   The Epstein-Barr virus BILF1 gene encodes a G protein-coupled receptor that inhibits phosphorylation of RNA-dependent protein kinase [J].
Beisser, PS ;
Verzijl, D ;
Gruijthuijsen, YK ;
Beuken, E ;
Smit, MJ ;
Leurs, R ;
Bruggeman, CA ;
Vink, C .
JOURNAL OF VIROLOGY, 2005, 79 (01) :441-449
12345678910