Robustaflavone, a naturally occurring biflavanoid, is a potent non-nucleoside inhibitor of hepatitis B virus replication in vitro

被引：30

作者：

Lin, YM

Zembower, DE

Flavin, MT

Schure, RM

Anderson, HM

Korba, BE

Chen, FC

机构：

[1] MEDICHEM RES INC,LEMONT,IL 60439

[2] GEORGETOWN UNIV,MED CTR,DIV MOL VIROL & IMMUNOL,ROCKVILLE,MD 20852

[3] TAMKANG UNIV,DEPT CHEM,TAIPEI,TAIWAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 17期

关键词：

D O I：

10.1016/S0960-894X(97)00422-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Robustaflavone, a naturally occurring biflavanoid isolated from the seed kernel extract of Rhus succedanea, was found to be a potent in vitro inhibitor of hepatitis B, with an effective concentration (EC50) of 0.25 mu M and an in vitro selectivity index (IC50/EC90) of 153. Further studies suggested that inhibition of HBV DNA polymerase is the mechanism of action. (C) 1997 Elsevier Science Ltd.

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页码：2325 / 2328

页数：4

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