Psychobiotics: A new approach for treating mental illness?

被引:84
作者
Misra, Snigdha [1 ]
Mohanty, Debapriya [2 ]
机构
[1] Int Med Univ, Dept Nutr & Dietet, Sch Hlth Sci, 126 Jalan Jalil Perkasa,19, Kuala Lumpur 57000, Malaysia
[2] Orissa Univ Agr & Technol, Dept Microbiol, Ctr Post Grad Studies, Bhubaneswar, Odisha, India
关键词
Gut microbes; psychobiotics; mental illness; MAJOR DEPRESSIVE DISORDER; GUT-BRAIN AXIS; LACTOBACILLUS-HELVETICUS; FERMENTED MILK; BEHAVIOR; MICROBIOME; PROBIOTICS; ANXIETY; DIET; SYMPTOMS;
D O I
10.1080/10408398.2017.1399860
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Gut microbiomes may have a significant impact on mood and cognition, which is leading experts towards a new frontier in neuroscience. Studies have shown that increase in the amount of good bacteria in the gut can curb inflammation and cortisol level, reduces symptoms of depression and anxiety, lowers stress reactivity, improves memory and even lessens neuroticism and social anxiety. This shows that, probably the beneficial gut bacteria or probiotics function mechanistically as delivery vehicles for neuroactive compounds. Thus, a psychobiotic is a live organism, when ingested in adequate amounts, produces a health benefit in patients suffering from psychiatric illness. Study of these novel class of probiotics may open up the possibility of rearrangement of intestinal microbiota for effective management of various psychiatric disorders.
引用
收藏
页码:1230 / 1236
页数:7
相关论文
共 44 条
[1]   Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats [J].
Ait-Belgnaoui, Afifa ;
Durand, Henri ;
Cartier, Christel ;
Chaumaz, Gilles ;
Eutamene, Helene ;
Ferrier, Laurent ;
Houdeau, Eric ;
Fioramonti, Jean ;
Bueno, Lionel ;
Theodorou, Vassilia .
PSYCHONEUROENDOCRINOLOGY, 2012, 37 (11) :1885-1895
[2]   Clinical and metabolic response to probiotic administration in patients with major depressive disorder: A randomized, double-blind, placebo-controlled trial [J].
Akkasheh, Ghodarz ;
Kashani-Poor, Zahra ;
Tajabadi-Ebrahimi, Maryam ;
Jafari, Parvaneh ;
Akbari, Hossein ;
Taghizadeh, Mohsen ;
Memarzadeh, Mohammad Reza ;
Asemi, Zatollah ;
Esmaillzadeh, Ahmad .
NUTRITION, 2016, 32 (03) :315-320
[3]   Combination of Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 reduces post-myocardial infarction depression symptoms and restores intestinal permeability in a rat model [J].
Arseneault-Breard, Jessica ;
Rondeau, Isabelle ;
Gilbert, Kim ;
Girard, Stephanie-Anne ;
Tompkins, Thomas A. ;
Godbout, Roger ;
Rousseau, Guy .
BRITISH JOURNAL OF NUTRITION, 2012, 107 (12) :1793-1799
[4]   γ-Aminobutyric acid production by culturable bacteria from the human intestine [J].
Barrett, E. ;
Ross, R. P. ;
O'Toole, P. W. ;
Fitzgerald, G. F. ;
Stanton, C. .
JOURNAL OF APPLIED MICROBIOLOGY, 2012, 113 (02) :411-417
[5]   Impact of consuming a milk drink containing a probiotic on mood and cognition [J].
Benton, D. ;
Williams, C. ;
Brown, A. .
EUROPEAN JOURNAL OF CLINICAL NUTRITION, 2007, 61 (03) :355-361
[6]   Microbes and the gut-brain axis [J].
Bercik, P. ;
Collins, S. M. ;
Verdu, E. F. .
NEUROGASTROENTEROLOGY AND MOTILITY, 2012, 24 (05) :405-413
[7]  
Bercik P., 2013, NEUROGASTROENT MOTIL, V23, P1132
[8]   Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve [J].
Bravo, Javier A. ;
Forsythe, Paul ;
Chew, Marianne V. ;
Escaravage, Emily ;
Savignac, Helene M. ;
Dinan, Timothy G. ;
Bienenstock, John ;
Cryan, John F. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (38) :16050-16055
[9]   Involvement of gut microbiota in the development of low-grade inflammation and type 2 diabetes associated with obesity [J].
Cani, Patrice D. ;
Osto, Melania ;
Geurts, Lucie ;
Everard, Amandine .
GUT MICROBES, 2012, 3 (04) :279-288
[10]  
CRITCHFIELD J, 2011, ARTICLE, DOI DOI 10.1155/2011/161358