Interaction of Amphotericin B/Sphingomyelin Mono layers at the Air/Water Interface

被引：2

作者：

Qiao Jin-Jing ^{[1
]}

Sun Run-Guang ^{[1
]}

Hao Chang-Chun ^{[1
]}

Yang Jing ^{[1
]}

Ma Xiu-Zi ^{[1
]}

Wang Xiao-Mei ^{[1
]}

机构：

[1] Shaanxi Normal Univ, Lab Biophys & Biomed, Coll Phys & Informat Technol, Xian 710062, Peoples R China

来源：

CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE | 2013年 / 34卷 / 09期

关键词：

Amphotericin B; Monolayer; Sphingomyelin; pi-A Curve; Atomic force microscopy; THERMODYNAMIC CHARACTERISTICS; MIXED MONOLAYERS; CERAMIDE; BEHAVIOR;

D O I：

10.7503/cjcu20121137

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this work, we chose sphingomyelin(SM) as the basic components of the monolayer, which is widespreaded in mammalian cells and takes an important role in biochemical reactions. Different proportion of amphotericin B/sphingomyelin monolayer's surface pressure and mean molecular area(pi-A) curve was investigated by the Langmuir-Blodgett (LB) films technology, thermodynamic characteristics were also analyzed based on the pi-A curve and the morphological changes of the surface were observed by atomic force microscopy (AFM). The results showed that the compressibility, stability and thermodynamic characteristics of AmB/SM monolayer depended on the mole faction of AmB and the surface pressure obviously. This may be related to the inhibition of Amphotericin B.

引用

页码：2125 / 2130

页数：6

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