O2-Protected diazeniumdiolate-modified silica nanoparticles for extended nitric oxide release from dental composites

被引：26

作者：

Carpenter, Alexis W. ^{[1
]}

Reighard, Katelyn P. ^{[1
]}

Saavedra, Joseph E. ^{[2
]}

Schoenfisch, Mark H. ^{[1
]}

机构：

[1] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA

[2] NCI, Basic Sci Program, SAIC Frederick, Frederick, MD 21702 USA

来源：

BIOMATERIALS SCIENCE | 2013年 / 1卷 / 05期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

FUNCTIONALIZATION; XEROGELS; ADHESION; DELIVERY;

D O I：

10.1039/c3bm00153a

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

O-2-Protected N-diazeniumdiolate-based silanes were grafted onto mesoporous silica nanoparticles to yield a scaffold with an NO payload of 2.4 mu mol NO per mg and NO release half-life of 23 d. Adhesion of Streptococcus mutans to dental restorative materials doped with these NO-releasing particles was reduced by 3-log compared to controls.

引用

页码：456 / 459

页数：4

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