Preparation and characterization of lyophilized liposomes with incorporated quercetin

被引：36

作者：

Alexopoulou, E

Georgopoulos, A

Kagkadis, KA

Demetzos, C ^{[1
]}

机构：

[1] Sch Pharm, Dept Pharmaceut Technol, Athens 15771, Greece

[2] VIANEX SA, Athens 15351, Greece

来源：

JOURNAL OF LIPOSOME RESEARCH | 2006年 / 16卷 / 01期

关键词：

liposomes; flavonoids; lyophilization;

D O I：

10.1080/08982100500528594

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Liposomes composed of egg-phosphatidylcholine (EPC) incorporating quercetin (QR) were prepared by the thin-film hydration method (TFHM) and the monophase solution method (MSM). A rapid and slow freeze-drying process was applied for both laboratory and industrial scales. The purpose of this study was to compare the two methods of liposome preparation, and further determine whether the lyophilization process affects the liposome physicochemical characteristics (size, polydispersity index, and zeta-potential) and incorporation of quercetin.

引用

页码：17 / 25

页数：9

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