Effect of Repeated Oral Administration of Bifenthrin on Lipid Peroxidation and Anti-oxidant Parameters in Wistar Rats

被引：22

作者：

Dar, Muneer Ahmad ^{[1
]}

Khan, Adil Mehraj ^{[1
]}

Raina, Rajinder ^{[1
]}

Verma, Pawan Kumar ^{[1
]}

Sultana, Mudasir ^{[1
]}

机构：

[1] Shere Kashmir Univ Agr Sci & Technol, Dept Vet Pharmacol & Toxicol, Jammu, India

来源：

BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY | 2013年 / 91卷 / 01期

关键词：

Oxidative stress; Lipid peroxidation; Bifenthrin; Rats; INDUCED OXIDATIVE DAMAGE; DELTAMETHRIN; ATTENUATION; SELENIUM; STRESS; GST;

D O I：

10.1007/s00128-013-1022-7

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The oxidative stress-inducing potential of the pyrethroid insecticide, bifenthrin, was evaluated in rats at 5.8 mg/kg body weight once daily for 20 or 30 days. Bifenthrin treated animals showed significantly increased lipid peroxidation, evidenced by increased blood malondialdehyde levels. Blood glutathione levels and activities of catalase and glutathione peroxidase decreased significantly in the bifenthrin treated animals after both 20 and 30 days of treatment, whereas, the activities of superoxide dismutase and glutathione S-transferase decreased significantly only on the 30th day. In conclusion, bifenthrin has a potential to induce severe oxidative stress in rats exposed to sublethal concentrations.

引用

页码：125 / 128

页数：4

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