Liposomes, micelles and microemulsions as new delivery systems for cytotoxic alkaloids

被引：33
作者：
Cortesi, R
Nastruzzi, C
机构：
[1] Ist Chim & Tecnol Farm, I-06100 Perugia, Italy
[2] Univ Ferrara, Dipartimento Sci Farmaceut, I-44100 Ferrara, Italy
来源：
PHARMACEUTICAL SCIENCE & TECHNOLOGY TODAY | 1999年 / 2卷 / 07期
关键词：
D O I：
10.1016/S1461-5347(99)00171-6
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
This review describes the design and performance of specialized delivery systems, such as liposomes, micellar solutions and microemulsions, for the administration of cytotoxic alkaloids. Special attention is directed towards three types of compound, Vinca, Camptotheca and Taxus alkaloids, which have been previously indicated as of promise as antitumour agents but which still present serious drawbacks. In this respect, this review analyses different delivery strategies that are able to substantially improve the therapeutic applicability of such antitumour drugs.
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页码：288 / 298
页数：11
相关论文
共 78 条
[1]   PREPARATION OF MODEL MEMBRANES FOR SKIN PERMEABILITY STUDIES USING STRATUM-CORNEUM LIPIDS [J].
ABRAHAM, W ;
DOWNING, DT .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1989, 93 (06) :809-813
[2]   A MIXED MICELLAR FORMULATION SUITABLE FOR THE PARENTERAL ADMINISTRATION OF TAXOL [J].
ALKANONYUKSEL, H ;
RAMAKRISHNAN, S ;
CHAI, HB ;
PEZZUTO, JM .
PHARMACEUTICAL RESEARCH, 1994, 11 (02) :206-212
[3]  
Attwood D., 1994, Drugs Pharm. Sci, V66, P31
[4]  
BARTOLAZZI A, 1989, In Vivo (Attiki), V3, P383
[5]   INTERACTION OF VINBLASTINE SULFATE WITH ARTIFICIAL PHOSPHOLIPID-MEMBRANES - A STUDY BY DIFFERENTIAL SCANNING CALORIMETRY AND SPIN LABELING [J].
BERLEUR, F ;
ROMAN, V ;
JASKIEROWICZ, D ;
DAVELOOSE, D ;
LETERRIER, F ;
TERMINASSIANSARAGA, L ;
MADELMONT, G .
BIOCHEMICAL PHARMACOLOGY, 1985, 34 (17) :3081-3086
[6]   ANTITRYPANOSOMAL ACTIVITY OF CAMPTOTHECIN ANALOGS - STRUCTURE-ACTIVITY CORRELATIONS [J].
BODLEY, AL ;
WANI, MC ;
WALL, ME ;
SHAPIRO, TA .
BIOCHEMICAL PHARMACOLOGY, 1995, 50 (07) :937-942
[7]   Vincristine-induced dermal toxicity is significantly reduced when the drug is given in liposomes [J].
Boman, NL ;
Tron, VA ;
Bally, MB ;
Cullis, PR .
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 1996, 37 (04) :351-355
[8]  
Brandau R., 1982, DERMAL TRANSDERMAL A
[9]   STABILIZATION OF TOPOTECAN IN LOW PH LIPOSOMES COMPOSED OF DISTEAROYLPHOSPHATIDYLCHOLINE [J].
BURKE, TG ;
GAO, X .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1994, 83 (07) :967-969
[10]  
Cabanes A, 1998, INT J ONCOL, V12, P1035
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