Phase II Trial of Parathyroid Hormone after Double Umbilical Cord Blood Transplantation

被引：19

作者：

Ballen, Karen ^{[1
]}

Mendizabal, Adam M. ^{[2
]}

Cutler, Corey ^{[3
]}

Politikos, Ioannis ^{[4
]}

Jamieson, Katarzyna ^{[5
]}

Shpall, Elizabeth J. ^{[6
]}

Dey, Bimalangshu R. ^{[1
]}

Attar, Eyal ^{[1
]}

McAfee, Steven ^{[1
]}

Delaney, Colleen ^{[7
]}

McCarthy, Philip ^{[8
]}

Ball, Edward D. ^{[9
]}

Kamble, Ram ^{[10
]}

Avigan, David ^{[4
]}

Maziarz, Richard T. ^{[11
]}

Ho, Vincent T. ^{[3
]}

Koreth, John ^{[3
]}

Alyea, Edwin ^{[3
]}

Soiffer, Robert ^{[3
]}

Wingard, John R. ^{[5
]}

Boussiotis, Vicki ^{[4
]}

Spitzer, Thomas R. ^{[1
]}

Antin, Joseph H. ^{[3
]}

机构：

[1] Massachusetts Gen Hosp, Div Hematol Oncol, Dept Med, Boston, MA 02114 USA

[2] EMMES Corp, Rockville, MD USA

[3] Dana Farber Canc Inst, Div Hematol Malignancies, Boston, MA 02115 USA

[4] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

[5] Univ Florida, Ctr Canc, Gainesville, FL USA

[6] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[7] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA

[8] Roswell Pk Canc Inst, Buffalo, NY 14263 USA

[9] Univ Calif San Diego, La Jolla, CA 92093 USA

[10] Baylor Coll Med, Houston, TX 77030 USA

[11] Oregon Hlth & Sci Univ, Knight Canc Ctr, Portland, OR 97201 USA

来源：

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2012年 / 18卷 / 12期

关键词：

Transplantation; Cord blood; Engraftment; PROGENITOR CELLS; OSTEOBLASTS; ADULTS; EXPANSION;

D O I：

10.1016/j.bbmt.2012.06.016

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Transplantation of 1 or 2 umbilical cord blood products is a useful alternative stem cell source. However, the limited number of stem cells in each infusion results in slow engraftment. In mouse models, administration of parathyroid hormone (PTH) is an effective way to enhance the ability of limited numbers of hematopoietic stem cells to support hematopoiesis. In this study, patients received either a myeloablative or a reduced-intensity double umbilical cord blood transplantation, followed by PTH at 100 mu g/day for 28 days. Thirteen patients (median age, 42 years) were enrolled. All patients engrafted; the median time to neutrophil and platelet engraftment of > 20 x 10(9) cells/L was 30 days and 61 days, respectively. The incidence of grade II-IV acute GVHD was 38.5% at day 100. Four deaths occurred before day 100, prompting early study closure. No patient who received a myeloablative regimen relapsed. Overall survival at 6 months after transplantation was 62%, and disease-free survival at 2 years was 39%. At the dose and schedule studied, there was no evidence that PTH influenced blood count recovery. Biol Blood Marrow Transplant 18: 1851-1858 (2012) (c) 2012 American Society for Blood and Marrow Transplantation

引用

页码：1851 / 1858

页数：8

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