Epstein-Barr virus in oral proliferative verrucous leukoplakia and squamous cell carcinoma:: A preliminary study

被引：0

作者：

Bagan, Jose V. ^{[1
]}

Jimenez, Yolanda

Murillo, Judith

Poveda, Rafael

Diaz, Jose M.

Gavalda, Carmen

Margaix, Maria

Scully, Crispian ^{[2
,3
]}

Alberola, Trinidad M. ^{[4
]}

Torres Puente, Manuela ^{[4
]}

Perez Alonso, Manuel ^{[4
,5
]}

机构：

[1] Univ Valencia, Univ Gen Hosp, Dept Stomatol, Serv Estomatol, Valencia 46014, Spain

[2] UCL, Int Ctr Excellence Dent, London, England

[3] UCL, Eastman Dent Inst Oral Hlth Care Sci, London, England

[4] Sistemas Genom SL, Unidad Oncol Mol, Div Biomed, Paterna, Spain

[5] Univ Valencia, Dept Genet, E-46100 Burjassot, Spain

来源：

MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL | 2008年 / 13卷 / 02期

关键词：

proliferative verrucous leukoplakia; carcinoma; Epstein-Barr virus;

D O I：

暂无

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

The aim of this study was to analyze proliferative verrucous leukoplakia (PVL) and oral squamous cell carcinoma (OSCC) for the possible presence of Epstein- Barr virus (EBV). We studied three groups: Sub- Group 1 was composed of 10 patients with PVL, (6 of whom had developed OSCC); Sub- Group 2 comprised 5 patients with OSCC but no preceding PVL; and Sub-Group 3 were 5 controls with clinically normal oral mucosa. Oral biopsies from all cases were examined for Epstein-Barr virus (EBV) by nested PCR. EBV was detected in 60% of Sub- Group 1 patients (PVL) and in 40% of Sub- Group 2 (OSCC), but in 0% of SubGroup 3 (controls).

引用

页码：E110 / E113

页数：4

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