Epstein-Barr virus in oral proliferative verrucous leukoplakia and squamous cell carcinoma:: A preliminary study

被引：0

作者：

Bagan, Jose V. ^{[1
]}

Jimenez, Yolanda

Murillo, Judith

Poveda, Rafael

Diaz, Jose M.

Gavalda, Carmen

Margaix, Maria

Scully, Crispian ^{[2
,3
]}

Alberola, Trinidad M. ^{[4
]}

Torres Puente, Manuela ^{[4
]}

Perez Alonso, Manuel ^{[4
,5
]}

机构：

[1] Univ Valencia, Univ Gen Hosp, Dept Stomatol, Serv Estomatol, Valencia 46014, Spain

[2] UCL, Int Ctr Excellence Dent, London, England

[3] UCL, Eastman Dent Inst Oral Hlth Care Sci, London, England

[4] Sistemas Genom SL, Unidad Oncol Mol, Div Biomed, Paterna, Spain

[5] Univ Valencia, Dept Genet, E-46100 Burjassot, Spain

来源：

MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL | 2008年 / 13卷 / 02期

关键词：

proliferative verrucous leukoplakia; carcinoma; Epstein-Barr virus;

D O I：

暂无

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

The aim of this study was to analyze proliferative verrucous leukoplakia (PVL) and oral squamous cell carcinoma (OSCC) for the possible presence of Epstein- Barr virus (EBV). We studied three groups: Sub- Group 1 was composed of 10 patients with PVL, (6 of whom had developed OSCC); Sub- Group 2 comprised 5 patients with OSCC but no preceding PVL; and Sub-Group 3 were 5 controls with clinically normal oral mucosa. Oral biopsies from all cases were examined for Epstein-Barr virus (EBV) by nested PCR. EBV was detected in 60% of Sub- Group 1 patients (PVL) and in 40% of Sub- Group 2 (OSCC), but in 0% of SubGroup 3 (controls).

引用

页码：E110 / E113

页数：4

共 25 条

[1]

Anwar M, 2005, J EXP CLIN CANC RES, V24, P379

[2] Lack of association between proliferative verrucous leukoplakia and human papillomavirus infection [J].

Bagan, Jose V. ;

Jimenez, Yolanda ;

Murillo, Judith ;

Gavalda, Carmen ;

Poveda, Rafael ;

Scully, Crispian ;

Alberola, Trinidad M. ;

Torres-Puente, Manuela ;

Perez-Alonso, Manuel .

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2007, 65 (01) :46-49

[3] Proliferative verrucous leukoplakia:: unusual locations of oral squamous cell carcinomas, and field cancerization as shown by the appearance of multiple OSCCs [J].

Bagán, JV ;

Murillo, J ;

Poveda, R ;

Gavaldá, C ;

Jiménez, Y ;

Scully, C .

ORAL ONCOLOGY, 2004, 40 (04) :440-443

[4] Proliferative verrucous leukoplakia: high incidence of gingival squamous cell carcinoma [J].

Bagan, JV ;

Jimenez, Y ;

Sanchis, JM ;

Poveda, R ;

Milian, MA ;

Murillo, J ;

Scully, C .

JOURNAL OF ORAL PATHOLOGY & MEDICINE, 2003, 32 (07) :379-382

[5] Proliferative verrucous vs conventional leukoplakia: no significantly increased risk of HPV infection [J].

Campisi, G ;

Giovannelli, L ;

Ammatuna, P ;

Capra, G ;

Colella, G ;

Di Liberto, C ;

Gandolfo, S ;

Pentenero, M ;

Carrozzo, M ;

Serpico, R ;

D'Angelo, M .

ORAL ONCOLOGY, 2004, 40 (08) :835-840

[6]

Eversole L R, 2000, J Calif Dent Assoc, V28, P922

[7]

Feller Liviu, 2006, J Int Acad Periodontol, V8, P67

[8] Proliferative verrucous leukoplakia of the gingiva [J].

Fettig, A ;

Pogrel, MA ;

Silverman, S ;

Bramanti, TE ;

Da Costa, M ;

Regezi, JA .

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS, 2000, 90 (06) :723-730

[9] Molecular piracy: the viral link to carcinogenesis [J].

Flaitz, CM ;

Hicks, MJ .

ORAL ONCOLOGY, 1998, 34 (06) :448-453

[10] Current topics in the epidemiology of oral cavity and oropharyngeal cancers [J].

Gillison, Maura L. .

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2007, 29 (08) :779-792

← 1 2 3 →