Exploiting a novel size exclusion phenomenon for enantioselective acid/base cascade catalysis

被引：34

作者：

Muratore, Michael E. ^{[1
]}

Shi, Lei ^{[1
]}

Pilling, Adam W. ^{[2
]}

Storer, R. Ian ^{[3
]}

Dixon, Darren J. ^{[1
]}

机构：

[1] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England

[2] Univ Manchester, Sch Chem, Manchester M13 9PL, Lancs, England

[3] Pfizer Neusentis, Cambridge CB21 6GS, England

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 51期

关键词：

CHIRAL BRONSTED ACID; ACYLIMINIUM CYCLIZATION CASCADES; COUNTERANION-DIRECTED CATALYSIS; TRANSITION-METAL CATALYSIS; SOLVENT-FREE CONDITIONS; SITE-ISOLATED BASE; STAR POLYMERS; EFFICIENT; BEMP; EPOXIDATION;

D O I：

10.1039/c2cc32258g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel size exclusion phenomenon between PS-BEMP and sterically bulky BPAs, has been discovered and exploited in a one-pot base-catalysed Michael addition/acid-catalysed enantioselective N-acyliminium cyclisation cascade, allowing the preparation of structurally complex beta-carbolines with moderate to good enantiocontrol.

引用

页码：6351 / 6353

页数：3

共 28 条

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