Sex differences in mutation rate in higher primates estimated from AMG intron sequences

被引：47

作者：

Huang, W ^{[1
]}

Chang, BHJ ^{[1
]}

Gu, X ^{[1
]}

HewettEmmett, D ^{[1
]}

Li, WH ^{[1
]}

机构：

[1] UNIV TEXAS,SCH PUBL HLTH,CTR HUMAN GENET,HOUSTON,TX 77225

来源：

JOURNAL OF MOLECULAR EVOLUTION | 1997年 / 44卷 / 04期

关键词：

sex difference in mutation rate; male-driven evolution; amelogenin gene; intron sequences; higher primates;

D O I：

10.1007/PL00006166

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To study sex differences in mutation rate in primates, we sequenced the third introns of the AMGX and AMGY genes from humans, orangutans, and squirrel monkeys and estimated that the male-to-female ratio of mutation rate is alpha = 5.14 with the 95% confidence interval (2.42, 16.6). Combining this data set and the data sets from ZFX/ZFY and SMCX/SMCY introns, we obtained an estimate of alpha = 5.06 with the 95% confidence interval reduced to (3.24, 8.79). The alpha value is significantly higher in higher primates than in rodents.

引用

页码：463 / 465

页数：3

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