Copper-Catalyzed C-N Bond Formation with N-Heterocycles and Aryl Halides

被引：26
作者：
Boswell, Mikki G. [1 ]
Yeung, Fanny G. [1 ]
Wolf, Christian [1 ]
机构：
[1] Georgetown Univ, Dept Chem, Washington, DC 20057 USA
来源：
SYNLETT | 2012年 / 08期
基金：
美国国家科学基金会;
关键词：
copper; cross-coupling; N-heterocycles; aryl halides; microwave; CROSS-COUPLING REACTIONS; NITROGEN-CONTAINING HETEROCYCLES; LONG-LIVED CATALYSTS; ROOM-TEMPERATURE; AMINO-ACID; PALLADIUM PRECATALYSTS; EFFICIENT CATALYST; ARYLBORONIC ACID; HIGHLY EFFICIENT; AQUEOUS AMMONIA;
D O I：
10.1055/s-0031-1290827
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The microwave-assisted, cuprous oxide catalyzed coupling of aryl bromides and iodides with imidazole, benzimidazole, pyrazole, or triazole was found to give a wide range of N-aryl heteroaromatic products in good to high yields. Aryl dibromides undergo selective monosubstitution even in the presence of large excess of N-heterocyclic nucleophiles which leaves the second aryl bromide functionality intact for further derivatization.
引用
收藏
页码：1240 / 1244
页数：5
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