The contribution of rodent models to the pathological assessment of flaviviral infections of the central nervous system

被引：29

作者：

Clark, David C. ^{[1
,2
]}

Brault, Aaron C. ^{[3
]}

Hunsperger, Elizabeth ^{[4
]}

机构：

[1] Univ Calif Davis, Sch Vet Med, Ctr Vectorborne Dis, Davis, CA 95616 USA

[2] Univ Calif Davis, Sch Vet Med, Dept Pathol Microbiol & Immunol, Davis, CA 95616 USA

[3] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80521 USA

[4] Ctr Dis Control & Prevent, Div Vector Borne Dis, San Juan, PR 00920 USA

来源：

ARCHIVES OF VIROLOGY | 2012年 / 157卷 / 08期

关键词：

WEST-NILE-VIRUS; ST-LOUIS ENCEPHALITIS; TICK-BORNE ENCEPHALITIS; BLOOD-BRAIN-BARRIER; MURRAY VALLEY ENCEPHALITIS; TOLL-LIKE RECEPTOR-3; JAPANESE ENCEPHALITIS; IN-VITRO; EQUINE ENCEPHALOMYELITIS; NEURONAL DEATH;

D O I：

10.1007/s00705-012-1337-4

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Members of the genus Flavivirus are responsible for a spectrum of important neurological syndromes in humans and animals. Rodent models have been used extensively to model flavivirus neurological disease, to discover host-pathogen interactions that influence disease outcome, and as surrogates to determine the efficacy and safety of vaccines and therapeutics. In this review, we discuss the current understanding of flavivirus neuroinvasive disease and outline the host, viral and experimental factors that influence the outcome and reliability of virus infection of small-animal models.

引用

页码：1423 / 1440

页数：18

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