The influence of stroke risk factors and comorbidities on assessment of stroke therapies in humans and animals

被引：31
作者：
Ankolekar, Sandeep
Rewell, Sarah [2 ]
Howells, David W. [2 ]
Bath, Philip M. W. [1 ]
机构：
[1] Univ Nottingham, Div Stroke, Stroke Trials Unit, Nottingham NG5 1PB, England
[2] Melbourne Brain Ctr, Florey Neurosci Inst, Heidelberg, Vic, Australia
来源：
INTERNATIONAL JOURNAL OF STROKE | 2012年 / 7卷 / 05期
基金：
澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;
关键词：
acute stroke; animal models; diabetes; hypertension; risk factors; stroke therapies; FOCAL CEREBRAL-ISCHEMIA; BLOOD-BRAIN-BARRIER; SPONTANEOUSLY HYPERTENSIVE-RATS; CORONARY-HEART-DISEASE; NITRIC-OXIDE SYNTHASE; AUTOSOMAL-DOMINANT ARTERIOPATHY; TISSUE-PLASMINOGEN ACTIVATOR; ALL-CAUSE MORTALITY; ATRIAL-FIBRILLATION; ALCOHOL-CONSUMPTION;
D O I：
10.1111/j.1747-4949.2012.00802.x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The main driving force behind the assessment of novel pharmacological agents in animal models of stroke is to deliver new drugs to treat the human disease rather than to increase knowledge of stroke pathophysiology. There are numerous animal models of the ischaemic process and it appears that the same processes operate in humans. Yet, despite these similarities, the drugs that appear effective in animal models have not worked in clinical trials. To date, tissue plasminogen activator is the only drug that has been successfully used at the bedside in hyperacute stroke management. Several reasons have been put forth to explain this, but the failure to consider comorbidities and risk factors common in older people is an important one. In this article, we review the impact of the risk factors most studied in animal models of acute stroke and highlight the parallels with human stroke, and, where possible, their influence on evaluation of therapeutic strategies.
引用
收藏
页码：386 / 397
页数：12
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