Open-Label Study of Absorption and Clearance of 1% Voriconazole Eye Drops

被引:10
作者
Neoh, Chin Fen [1 ,2 ]
Leung, Lok [3 ,9 ]
Chan, Elsie [4 ]
Al-Badriyeh, Daoud [5 ]
Fullinfaw, Robert O. [6 ]
Jhanji, Vishal [4 ,7 ]
Vajpayee, Rasik B. [4 ,10 ,11 ,12 ]
Davies, Geoffrey E. [3 ,8 ]
Stewart, Kay [2 ]
Kong, David C. M. [2 ,13 ]
机构
[1] Univ Teknol MARA, Fac Pharm, CDDR Grp, Puncak Alam, Selangor, Malaysia
[2] Monash Univ, Fac Pharm & Pharmaceut Sci, Ctr Med Use & Safety, Parkville, Vic, Australia
[3] RVEEH, Dept Pharm, East Melbourne, Vic, Australia
[4] RVEEH, Ctr Eye Res Australia, Corneal Unit, East Melbourne, Vic, Australia
[5] Qatar Univ, Coll Pharm, Doha, Qatar
[6] Royal Melbourne Hosp, Melbourne Hlth Pathol, Special Chem, Parkville, Vic, Australia
[7] Chinese Univ Hong Kong, Hong Kong Eye Hosp, Dept Ophthalmol & Visual Sci, Kowloon, Hong Kong, Peoples R China
[8] Victoria Barracks Melbourne, Dept Def, Land Syst Div,Hlth Syst Program Off, Capabil Acquisit & Sustainment Grp,Integrated Sol, Southbank, Vic, Australia
[9] Canberra Hosp, Dept Pharm, Garran, ACT, Australia
[10] Vis Eye Inst, Melbourne, Vic, Australia
[11] Univ Melbourne, Sunshine Hosp, Western Acad Ctr, St Albans, Vic, Australia
[12] Univ Melbourne, Northern Hosp, Northern Acad Ctr, Epping, Vic, Australia
[13] Pharm Dept Ballarat Hlth Serv, Ballarat Cent, Vic, Australia
关键词
HUMAN AQUEOUS-HUMOR; FUNGAL KERATITIS; INFECTIONS; MANAGEMENT; STABILITY; HUMANS;
D O I
10.1128/AAC.00683-16
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Twenty participants undergoing elective cataract surgery received 1% voriconazole eye drops (1 drop per eye) either 20, 40, 60, or 80 min before surgery. Median voriconazole concentrations of 1.9 to 3.2 mg/liter in aqueous humor samples were attained over the first 80 min, which were higher than in vitro MIC90 values for typical fungi that cause keratitis.
引用
收藏
页码:6896 / 6898
页数:3
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