Open-Label Study of Absorption and Clearance of 1% Voriconazole Eye Drops

被引：10

作者：

Neoh, Chin Fen ^{[1
,2
]}

Leung, Lok ^{[3
,9
]}

Chan, Elsie ^{[4
]}

Al-Badriyeh, Daoud ^{[5
]}

Fullinfaw, Robert O. ^{[6
]}

Jhanji, Vishal ^{[4
,7
]}

Vajpayee, Rasik B. ^{[4
,10
,11
,12
]}

Davies, Geoffrey E. ^{[3
,8
]}

Stewart, Kay ^{[2
]}

Kong, David C. M. ^{[2
,13
]}

机构：

[1] Univ Teknol MARA, Fac Pharm, CDDR Grp, Puncak Alam, Selangor, Malaysia

[2] Monash Univ, Fac Pharm & Pharmaceut Sci, Ctr Med Use & Safety, Parkville, Vic, Australia

[3] RVEEH, Dept Pharm, East Melbourne, Vic, Australia

[4] RVEEH, Ctr Eye Res Australia, Corneal Unit, East Melbourne, Vic, Australia

[5] Qatar Univ, Coll Pharm, Doha, Qatar

[6] Royal Melbourne Hosp, Melbourne Hlth Pathol, Special Chem, Parkville, Vic, Australia

[7] Chinese Univ Hong Kong, Hong Kong Eye Hosp, Dept Ophthalmol & Visual Sci, Kowloon, Hong Kong, Peoples R China

[8] Victoria Barracks Melbourne, Dept Def, Land Syst Div,Hlth Syst Program Off, Capabil Acquisit & Sustainment Grp,Integrated Sol, Southbank, Vic, Australia

[9] Canberra Hosp, Dept Pharm, Garran, ACT, Australia

[10] Vis Eye Inst, Melbourne, Vic, Australia

[11] Univ Melbourne, Sunshine Hosp, Western Acad Ctr, St Albans, Vic, Australia

[12] Univ Melbourne, Northern Hosp, Northern Acad Ctr, Epping, Vic, Australia

[13] Pharm Dept Ballarat Hlth Serv, Ballarat Cent, Vic, Australia

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2016年 / 60卷 / 11期

关键词：

HUMAN AQUEOUS-HUMOR; FUNGAL KERATITIS; INFECTIONS; MANAGEMENT; STABILITY; HUMANS;

D O I：

10.1128/AAC.00683-16

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Twenty participants undergoing elective cataract surgery received 1% voriconazole eye drops (1 drop per eye) either 20, 40, 60, or 80 min before surgery. Median voriconazole concentrations of 1.9 to 3.2 mg/liter in aqueous humor samples were attained over the first 80 min, which were higher than in vitro MIC90 values for typical fungi that cause keratitis.

引用

页码：6896 / 6898

页数：3

共 15 条

[1]

Al-Badriyeh D, 2010, EXPERT REV PHARM OUT, V10, P623, DOI [10.1586/erp.10.69, 10.1586/ERP.10.69]

[2] Stability of extemporaneously prepared voriconazole ophthalmic solution [J].