Efficient synthesis of bifenazate

被引：9
作者：
Chee, Gaik-Lean [1 ]
机构：
[1] Crompton Co Cie, Res Labs, Guelph, ON N1H 6N3, Canada
来源：
SYNTHETIC COMMUNICATIONS | 2006年 / 36卷 / 15期
关键词：
bifenazate; diisopropyl azodicarboxylate; fluoroalcohols; 4-methoxybiphenyl; nitromethane;
D O I：
10.1080/00397910600636683
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of bifenazate using a two-step procedure has been accomplished with an overall yield of 26%. The procedure involved the Lewis acid-catalyzed electrophilic aromatic substitution of 4-methoxybiphenyl with diisopropyl azodicarcoxylate (DIAD) to give a hydrazinedicarboxylate intermediate that was then subjected to a decarboxylation reaction to give bifenazate.
引用
收藏
页码：2151 / 2156
页数：6
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