Case report of a patient with schizophrenia and a mutation in the insulin receptor substrate-4 gene

被引：0

作者：

Melkersson, Kristina ^{[1
]}

机构：

[1] Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden

来源：

NEUROENDOCRINOLOGY LETTERS | 2013年 / 34卷 / 03期

基金：

瑞典研究理事会;

关键词：

schizophrenia; psychotic disorder; mutation; X-chromosome; insulin receptor substrate-4 gene; GROWTH-FACTOR-I; NEGATIVE ASSOCIATION; IRS-4; GENE; POLYMORPHISMS; STIMULATION; HOMEOSTASIS; EXPRESSION; PROTEIN;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This report deals with a female patient with schizophrenia who was found to have a mutation in the insulin receptor substrate-4 gene that is located on chromosome Xq22.3. Since this mutation is expected to change amino acid coding from histidine to tyrosine and cause an altered insulin receptor substrate-4 protein, and the insulin receptor substrate-4 protein may be involved in neuronal growth and function in the brain, it is possible that it is this insulin receptor substrate-4 gene mutation that underlies this patient's schizophrenia development.

引用

页码：173 / 176

页数：4

共 23 条

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