Angiotensin-converting enzyme 2 (ACE2) receptor and SARS-CoV-2: Potential therapeutic targeting

被引：61

作者：

Sharifkashani, Sourena ^{[1
,2
]}

Bafrani, Melika Arab ^{[1
,3
]}

Khaboushan, Alireza Soltani ^{[1
,2
]}

Pirzadeh, Marzieh ^{[1
,4
]}

Kheirandish, Ali ^{[1
,5
]}

Bali, Hanie Yavarpour ^{[1
,4
]}

Hessami, Amirhossein ^{[1
,6
]}

Saghazadeh, Amene ^{[1
,7
]}

Rezaei, Nima ^{[7
,8
,9
]}

机构：

[1] Universal Sci Educ & Res Network USERN, Systemat Review & Meta Anal Expert Grp SRMEG, Tehran, Iran

[2] Univ Tehran Med Sci, Sch Med, Tehran, Iran

[3] Univ Tehran Med Sci, Students Sci Res Ctr SSRC, Tehran, Iran

[4] Babol Univ Med Sci, Student Res Comm, Babol, Iran

[5] Mazandaran Univ Med Sci, Sch Pharm, Student Res Comm, Sari, Iran

[6] Mazandaran Univ Med Sci, Sch Med, Student Res Comm, Sari, Iran

[7] Univ Tehran Med Sci, Res Ctr Immunodeficiencies, Childrens Med Ctr, Tehran, Iran

[8] Univ Tehran Med Sci, Sch Med, Dept Immunol, Tehran, Iran

[9] Universal Sci Educ & Res Network USERN, Network Immun Infect Malignancy & Autoimmun NIIMA, Tehran, Iran

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2020年 / 884卷

关键词：

ACE2; COVID-19; SARS-CoV2; Origin; Therapeutic; Transmission; CORONAVIRUS SPIKE PROTEIN; EXPRESSION; COVID-19; SERINE; PREVENTION; TMPRSS2; ORIGIN;

D O I：

10.1016/j.ejphar.2020.173455

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a beta coronavirus that uses the human angiotensin-converting enzyme 2 (ACE2) receptor as a point of entry. The present review discusses the origin and structure of the virus and its mechanism of cell entry followed by the therapeutic potentials of strategies directed towards SARS-CoV2-ACE2 binding, the renin-angiotensin system, and the kinin-kallikrein system. SARS-CoV2-ACE2 binding-directed approaches mainly consist of targeting receptor binding domain, ACE2 blockers, soluble ACE2, and host protease inhibitors. In conclusion, blocking or manipulating the SARS-CoV2-ACE2 binding interface perhaps offers the best tactic against the virus that should be treated as a fundamental subject of future research.

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页数：6

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