Sequential Conia-ene-type cyclization and Negishi coupling by cooperative functions of B(C6F5)3, ZnI2, Pd(PPh3)4 and an amine

被引：5

作者：

Cao, Min ^{[1
]}

Yesilcimen, Ahmet ^{[1
]}

Prasad, Soumil ^{[1
]}

Genova, Jason ^{[1
]}

Myers, Tanner ^{[1
]}

Wasa, Masayuki ^{[1
]}

机构：

[1] Boston Coll, Merkert Chem Ctr, Dept Chemistiy, Chestnut Hill, MA 02467 USA

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2020年 / 18卷 / 36期

关键词：

HIGHLY SELECTIVE SYNTHESIS; CATALYZED ALPHA-ARYLATION; PALLADIUM ENOLATE; BOND ACTIVATION; DIRECT MANNICH; ARYL; COMPLEXES; CHLORIDES; REAGENTS; BROMIDES;

D O I：

10.1039/d0ob01678k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We disclose a method for sequential Conia-ene-type cyclization/Negishi coupling for the union of alkynyl ketones and aryl iodides. This process is promoted through cooperative actions of Lewis acidic B(C6F5)(3), ZnI2, Pd-based complex, and a Bronsted basic amine. The three Lewis acid catalysts with potential overlapping functions play their independent roles as activators of carbonyl group, alkyne moiety, and alkenyl zinc intermediate, respectively. A variety of 1,2,3-substituted cyclopentenes can be synthesized with high efficiency.

引用

页码：7090 / 7093

页数：4

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