New cytotoxic polyacetylenes from the marine sponge Petrosia

被引：31

作者：

Lim, YJ

Kim, JS

Im, KS

Jung, JH ^{[1
]}

Lee, CO

Hong, J

Kim, D

机构：

[1] Pusan Natl Univ, Coll Pharm, Pusan 609735, South Korea

[2] Korea Res Inst Chem Technol, Taejon 305606, South Korea

[3] Korea Basic Sci Inst, Taejon, South Korea

[4] Inje Univ, Dept Chem, Kimhae, South Korea

来源：

JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 09期

关键词：

D O I：

10.1021/np9900371

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

New polyacetylenic alcohols with a C-45 carbon skeleton (2) and with an enone moiety in the alkyl chain (C-46, 1) were isolated from the marine sponge Petrosia sp. The gross structures of 1 and 2 were established by spectral methods, and the absolute stereochemistry was determined by-the modified Mosher's method. Compounds 1 and 2 displayed considerable cytotoxicity against a small panel of human solid tumor cell lines. Significant inhibitions on DNA replication by 1 and 2 were also observed which could be explanative of their cytotoxicity.

引用

页码：1215 / 1217

页数：3

共 7 条

[1] TANDEM MASS-SPECTROMETRY FOR COLLISIONAL ACTIVATION OF ALKALI-METAL-CATIONIZED FATTY-ACIDS - A METHOD FOR DETERMINING DOUBLE-BOND LOCATION [J].