Association between tumor necrosis factor β 252 A/G polymorphism and risk of gastric cancer: a meta-analysis

被引：8
作者：
Xu, Zhenglei [1 ]
Shi, Ruiyue [1 ]
Zhang, Ru [1 ]
Zhang, Dingguo [1 ]
Wang, Lisheng [1 ]
机构：
[1] Jinan Univ, Clin Med Coll 2, Shenzhen Peoples Hosp, Dept Gastroenterol, Shenzhen 518000, Guangdong, Peoples R China
来源：
TUMOR BIOLOGY | 2013年 / 34卷 / 06期
关键词：
Tumor necrosis factor beta; Gastric cancer; Meta-analysis; CYTOKINE GENE POLYMORPHISMS; SUSCEPTIBILITY; ADENOCARCINOMA; LYMPHOTOXIN; POPULATION;
D O I：
10.1007/s13277-013-0989-3
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Tumor necrosis factor beta (TNF-beta) 252 A/G polymorphism has been implicated to be associated with risk of gastric cancer, but previous studies showed inconsistent and inconclusive results. Therefore, we performed a meta-analysis to assess the association between TNF-beta 252 A/G polymorphism and gastric cancer risk. Relevant studies were searched from PubMed database. Odds ratios (OR) and 95 % confidence intervals (95% CI) were calculated to evaluate the strength of the associations between TNF-beta 252 A/G polymorphism and gastric cancer risk. Overall, 11 individual case-control studies with 2,270 cases and 4,404 controls were included in the final meta-analysis. Meta-analysis of total 11 studies showed that TNF-beta 252 A/G polymorphism was associated with the risk of gastric cancer (G vs. A: OR = 1.10, 95 % CI 1.02-1.19, P = 0.015; GG/AG vs. AA: OR = 1.21, 95 % CI 1.00-1.47, P = 0.049). Subgroup analysis by ethnicity showed that TNF-beta 252 A/G polymorphism was only associated with the risk of gastric cancer in Asians, but not Caucasians. The findings from the current meta-analysis suggest that TNF-beta 252 A/G polymorphism is associated with the risk of gastric cancer, especially in Asians.
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收藏
页码：4001 / 4005
页数：5
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