Cysteine cathepsins in the immune response

被引：110

作者：

Zavasnik-Bergant, T ^{[1
]}

Turk, B ^{[1
]}

机构：

[1] Jozef Stefan Inst, Dept Biochem & Mol Biol, SI-1000 Ljubljana, Slovenia

来源：

TISSUE ANTIGENS | 2006年 / 67卷 / 05期

关键词：

antigen presentation; arthritis; cathepsin; immune response; mull phenotype; protease;

D O I：

10.1111/j.1399-0039.2006.00585.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Antigen (Ag) processing by major histocompatibility complex class II (MHC) class II molecules is tightly linked with the proteases of the endosomal/lysosomal system. Cysteine (Cys) cathepsins, which constitute a major portion of this proteolytic system, have been found to have essential roles in both Ag processing and maturation of the MHC class II molecules. In this review, we will cover some specific functions of individual Cys cathepsins and particularly those most relevant to the immune system.

引用

页码：349 / 355

页数：7

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