This article examines the role of entrepreneurial behaviour, property rights and state effectiveness as determinants of national innovation. Entrepreneurial behaviour reflects not only risk-bearing and risk-sharing attitudes but also the capacity to undertake innovation activities. Besides, institutions also play an important role in formalising entrepreneurial behaviour that is crucial for a country's innovation. A comparison is made among three groups of countries-that is, factor-driven, efficiency-driven and innovation-driven economies. Panel-data econometric techniques are applied to undertake empirical analysis, using macro-level data covering a time period of 7 years (2010-2016). It is observed that entrepreneurial attitudes and entrepreneurial activities play an important role in determining innovation but the impact varies with the level of economic development. A U-shaped relationship is observed between innovation and entrepreneurial activities. Innovation-driven economies have strong property rights and effective policy implementation that help build the confidence of prospective entrepreneurs who are attracted by perceived opportunities. Therefore, perceived opportunities have a significant impact only in innovation-driven economies. Moreover, innovation is highly suppressed in fragile countries, that is, factor-driven economies that face serious market distortions and inefficiencies caused by weak property rights and state ineffectiveness. However, no significant relationship is found in efficiency-driven economies.