Cordycepin: A bioactive metabolite with therapeutic potential

被引：255

作者：

Tuli, Hardeep S. ^{[1
]}

Sharma, Anil K. ^{[1
]}

Sandhu, Sardul S. ^{[2
]}

Kashyap, Dharambir ^{[3
]}

机构：

[1] Maharishi Markandeshwar Univ, Dept Biotechnol, Mullana Ambala 133203, Haryana, India

[2] Rani Durgavati Univ, Dept Biol Sci, Jabalpur 482001, India

[3] PGIMER, Dept Histopathol, Chandigarh, Punjab, India

来源：

LIFE SCIENCES | 2013年 / 93卷 / 23期

关键词：

Cordyceps; Metabolite; Cordycepin; Mechanism; Therapeutic potential; HUMAN PLATELET-AGGREGATION; BREAST-CANCER CELLS; INDUCED MATRIX-METALLOPROTEINASE-9 EXPRESSION; ASCITES-TUMOR CELLS; MATRIX METALLOPROTEINASES; ESTROGEN-RECEPTOR; CARCINOMA-CELLS; TNF-ALPHA; INHIBITION; INTERLEUKIN-10;

D O I：

10.1016/j.lfs.2013.09.030

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Cytotoxic nucleoside analogues were the first chemotherapeutic agents for cancer treatment. Cordycepin, an active ingredient of the insect fungus Cordyceps militaris, is a category of compounds that exhibit significant therapeutic potential. Cordycepin has many intracellular targets, including nucleic acid (DNA/RNA), apoptosis and cell cycle, etc. Investigations of the mechanism of anti-cancer drugs have yielded important information for the design of novel drug targets in order to enhance anti-tumor activity with less toxicity to patients. This extensive review covers various molecular aspects of cordycepin interactions with its recognized cellular targets and proposes the development of novel therapeutic strategies for cancer treatment. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：863 / 869

页数：7

共 69 条

[1] Cancer cell: using inflammation to invade the host [J].