Synthesis of 3H, 14C and 13C6 labelled Sch 58235

被引：10

作者：

Hesk, D ^{[1
]}

Bignan, G ^{[1
]}

Lee, J ^{[1
]}

Yang, J ^{[1
]}

Voronin, K ^{[1
]}

Magatti, C ^{[1
]}

McNamara, P ^{[1
]}

Koharski, D ^{[1
]}

Hendershot, S ^{[1
]}

Saluja, S ^{[1
]}

Wang, S ^{[1
]}

机构：

[1] Schering Plough Corp, Res Inst, Kenilworth, NJ 07033 USA

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2002年 / 45卷 / 02期

关键词：

Sch; 58235; tritium; carbon-13; carbon-14; synthesis;

D O I：

10.1002/jlcr.539

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

H-3-Sch 58235 was prepared at a specific activity of 29.1 Ci/mmol by Ir(COD)(CY3P)PyPF6 catalysed exchange with tritium gas. C-14-Sch 58235 was prepared in three steps from p-hydroxy[ring-U-C-14]benzaldehyde with an overall radiochemical yield of 21%. C-13(6)-Sch 58235 was similarly prepared in three steps from p-hydroxy[ring-U-C-13(6)]benzaldehyde in an overall yield of 41%. Copyright (C) 2002 John Wiley Sons, Ltd.

引用

页码：145 / 155

页数：11

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