Novel quinolinequinone antitumor agents:: Structure-metabolism studies with NAD(P)H:quinone oxidoreductase (NQO1)

被引：34
作者：
Fryatt, T
Goroski, DT
Nilson, ZD
Moody, CJ
Beall, HD [1 ]
机构：
[1] Univ Montana, Dept Pharmaceut Sci, Missoula, MT 59812 USA
[2] Univ Exeter, Sch Chem, Exeter EX4 4QD, Devon, England
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 15期
关键词：
D O I：
10.1016/S0960-894X(99)00369-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The effects of functional group changes on the metabolism of novel quinolinequinones by recombinant human NAD(P)H:quinone oxidoreductase (NQO1) are described. Overall, the quinolinequinones were much better substrates for NQO1 than analogous indolequinones, with compounds containing heterocyclic substituents at C-2 being among the best substrates. (C) 1999 Elsevier Science Ltd. All rights reserved.
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页码：2195 / 2198
页数：4
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