A gradient of BMP activity specifies dorsal-ventral fates in early Xenopus embryos

被引：78
作者：
Dale, L [1 ]
Wardle, FC [1 ]
机构：
[1] UCL, Dept Anat & Dev Biol, London WC1E 6BT, England
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 1999年 / 10卷 / 03期
基金：
英国惠康基金;
关键词：
BMP-4; chordin; noggin; mesoderm; Tld; Xenopus;
D O I：
10.1006/scdb.1999.0308
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
BMP-4 is an extracellular signalling molecule belonging to the TGF-P superfamily that plays a central role in dorsoventral patterning in vertebrate gastrulae. We review the evidence indicating that BMP-4 acts as a morphogen, specifying dorsoventral positional values in concentration-dependent manner. An activity gradient of BMP-4 is established not by Simple diffusion from a localised source, but by diffusion of inhibitory binding proteins that act on a uniform level of BMP-4 protein. These in turn are regulated by the activity of tolloid-related metalloproteases, such as Xenopus xolloid and zebrafish tolloid.
引用
收藏
页码：319 / 326
页数：8
相关论文
共 59 条
  • [1] ALBANO RM, 1994, DEVELOPMENT, V120, P803
  • [2] Follistatin and Noggin are excluded from the zeabrafish organizer
    Bauer, H
    Meier, A
    Hild, M
    Stachel, S
    Economides, A
    Hazelett, D
    Harland, RN
    Hammerschmidt, M
    [J]. DEVELOPMENTAL BIOLOGY, 1998, 204 (02) : 488 - 507
  • [3] Cleavage of the BMP-4 antagonist chordin by zebrafish tolloid
    Blader, P
    Rastegar, S
    Fischer, N
    Strahle, U
    [J]. SCIENCE, 1997, 278 (5345) : 1937 - 1940
  • [4] DALE L, 1992, DEVELOPMENT, V115, P573
  • [5] DALE L, 1999, IN PRESS BIOESSAYS, V21
  • [6] A common plan for dorsoventral patterning in Bilateria
    DeRobertis, EM
    Sasai, Y
    [J]. NATURE, 1996, 380 (6569) : 37 - 40
  • [7] Dosch R, 1997, DEVELOPMENT, V124, P2325
  • [8] The dorsalizing and neural inducing gene follistatin is an antagonist of BMP-4
    Fainsod, A
    Deissler, K
    Yelin, R
    Marom, K
    Epstein, M
    Pillemer, G
    Steinbeisser, H
    Blum, M
    [J]. MECHANISMS OF DEVELOPMENT, 1997, 63 (01) : 39 - 50
  • [9] ON THE FUNCTION OF BMP-4 IN PATTERNING THE MARGINAL ZONE OF THE XENOPUS EMBRYO
    FAINSOD, A
    STEINBEISSER, H
    DEROBERTIS, EM
    [J]. EMBO JOURNAL, 1994, 13 (21) : 5015 - 5025
  • [10] Conservation of dorsal-ventral patterning in arthropods and chordates
    Ferguson, EL
    [J]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 1996, 6 (04) : 424 - 431
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