The new alpha-amino acid N-omega-hydroxy-nor-L-arginine: A high-affinity inhibitor of arginase well adapted to bind to its manganese cluster

被引：92

作者：

Custot, J

Moali, C

Brollo, M

Boucher, JL

Delaforge, M

Mansuy, D

Tenu, JP

Zimmermann, JL

机构：

[1] UNIV PARIS 05,URA 400 CNRS,CHIM & BIOCHIM PHARMACOL & TOXICOL LAB,F-75270 PARIS 06,FRANCE

[2] UNIV PARIS 11,CNRS,URA 1116,F-91405 ORSAY,FRANCE

[3] CEA SACLAY,DEPT BIOL CELLULAIRE & MOL,SECT BIOENERGET,F-91191 GIF SUR YVETTE,FRANCE

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1997年 / 119卷 / 17期

关键词：

D O I：

10.1021/ja970285o

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[No abstract available]

引用

页码：4086 / 4087

页数：2

共 15 条

[1]

ASH DE, 1982, J BIOL CHEM, V257, P9261

[2] HYDROXYGUANIDINES - NEW CLASS OF ANTIHYPERTENSIVE AGENTS [J].

BAILEY, DM ;

DEGRAZIA, CG ;

LAPE, HE ;

FRERING, R ;

FORT, D ;

SKULAN, T .

JOURNAL OF MEDICINAL CHEMISTRY, 1973, 16 (02) :151-156

[3] N-OMEGA-HYDROXY-L-ARGININE, AN INTERMEDIATE IN THE L-ARGININE TO NITRIC-OXIDE PATHWAY, IS A STRONG INHIBITOR OF LIVER AND MACROPHAGE ARGINASE [J].

BOUCHER, JL ;

CUSTOT, J ;

VADON, S ;

DELAFORGE, M ;

LEPOIVRE, M ;

TENU, JP ;

YAPO, A ;

MANSUY, D .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 203 (03) :1614-1621

[4] FACILE SYNTHESIS OF TERT-BUTYL ESTER OF N-PROTECTED AMINO-ACIDS WITH TERT-BUTYL BROMIDE [J].

CHEVALLET, P ;

GARROUSTE, P ;

MALAWSKA, B ;

MARTINEZ, J .

TETRAHEDRON LETTERS, 1993, 34 (46) :7409-7412

[5] N omega-hydroxyamino-alpha-amino acids as a new class of very strong inhibitors of arginases [J].

Custot, J ;

Boucher, JL ;

Vadon, S ;

Guedes, C ;

Dijols, S ;

Delaforge, M ;

Mansuy, D .

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 1996, 1 (01) :73-82

[6] INHIBITION OF RAT-LIVER ARGINASE BY AN INTERMEDIATE IN NO BIOSYNTHESIS, N-G-HYDROXY-L-ARGININE - IMPLICATIONS FOR THE REGULATION OF NITRIC-OXIDE BIOSYNTHESIS BY ARGINASE [J].

DAGHIGH, F ;

FUKUTO, JM ;

ASH, DE .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 202 (01) :174-180

[7] SYNTHESIS OF THE PUTATIVE L-ARGININE METABOLITE L-(N)-HYDROXYARGININE [J].

FELDMAN, PL .

TETRAHEDRON LETTERS, 1991, 32 (07) :875-878

[8]

HUNTER A, 1946, J BIOL CHEM, V157, P427

[9] Structure of a unique binuclear manganese cluster in arginase [J].

Kanyo, ZF ;

Scolnick, LR ;

Ash, DE ;

Christianson, DW .

NATURE, 1996, 383 (6600) :554-557

[10] DETERMINATION OF THE METAL-ION SEPARATION AND ENERGIES OF THE 3 LOWEST ELECTRONIC STATES OF DIMANGANESE(II,II) COMPLEXES AND ENZYMES - CATALASE AND LIVER ARGINASE [J].

KHANGULOV, SV ;

PESSIKI, PJ ;

BARYNIN, VV ;

ASH, DE ;

DISMUKES, GC .

BIOCHEMISTRY, 1995, 34 (06) :2015-2025

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