Lack of association between TNF-α polymorphisms and Alzheimer's disease in an Italian cohort

被引：13
作者：
Tedde, Andrea [1 ]
Putignano, Anna Laura [2 ]
Nacmias, Benedetta [1 ]
Bagnoli, Silvia [1 ]
Cellini, Elena [1 ]
Sorbi, Sandro [1 ]
机构：
[1] Univ Florence, Dept Neurol & Psychiat Sci, I-50139 Florence, Italy
[2] Univ Florence, Dept Clin Physiopathol, Med Genet Unit, I-50139 Florence, Italy
来源：
NEUROSCIENCE LETTERS | 2008年 / 446卷 / 2-3期
关键词：
Alzheimer's disease; TNF-alpha; Haplotypes; SNPs;
D O I：
10.1016/j.neulet.2008.09.044
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Tumor necrosis factor-alpha (TNF-alpha) is a pro-inflammatory cytokine that plays an important role in the inflammatory process that can be observed in Alzheimer's disease (AD) brain. Different functional promoter polymorphisms within genes modulating inflammation have been demonstrated to elevate the AD risk; thus, we studied five common variations within the promoter region of the TNF-alpha gene in 609 subjects (253 AD patients and 356 controls). No positive associations were found, confirming the greater part of previous studies. Moreover, we also investigated the combined haplotypes of the five different polymorphisms without finding a positive association. Thus, the present investigation does not support the proposal that common nucleoticle variations in the TNF-alpha gene can influence the development of AD at least in Italian population. (c) 2008 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：139 / 142
页数：4
相关论文
共 36 条
  • [1] Impact of the-308 TNF promoter polymorphism on the transcriptional regulation of the TNF gene: relevance to disease
    Abraham, LJ
    Kroeger, KM
    [J]. JOURNAL OF LEUKOCYTE BIOLOGY, 1999, 66 (04) : 562 - 566
  • [2] AISEN PS, 1994, AM J PSYCHIAT, V151, P1105
  • [3] Inflammation and Alzheimer's disease
    Akiyama, H
    Barger, S
    Barnum, S
    Bradt, B
    Bauer, J
    Cole, GM
    Cooper, NR
    Eikelenboom, P
    Emmerling, M
    Fiebich, BL
    Finch, CE
    Frautschy, S
    Griffin, WST
    Hampel, H
    Hull, M
    Landreth, G
    Lue, LF
    Mrak, R
    Mackenzie, IR
    McGeer, PL
    O'Banion, MK
    Pachter, J
    Pasinetti, G
    Plata-Salaman, C
    Rogers, J
    Rydel, R
    Shen, Y
    Streit, W
    Strohmeyer, R
    Tooyoma, I
    Van Muiswinkel, FL
    Veerhuis, R
    Walker, D
    Webster, S
    Wegrzyniak, B
    Wenk, G
    Wyss-Coray, T
    [J]. NEUROBIOLOGY OF AGING, 2000, 21 (03) : 383 - 421
  • [4] Association between the TNFα-308 A/G polymorphism and the onset-age of Alzheimer disease
    Alvarez, V
    Mata, IF
    González, P
    Lahoz, CH
    Martínez, C
    Peña, J
    Guisasola, LM
    Coto, E
    [J]. AMERICAN JOURNAL OF MEDICAL GENETICS, 2002, 114 (05): : 574 - 577
  • [5] Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database
    Bertram, Lars
    McQueen, Matthew B.
    Mullin, Kristina
    Blacker, Deborah
    Tanzi, Rudolph E.
    [J]. NATURE GENETICS, 2007, 39 (01) : 17 - 23
  • [6] TNFα plus IFNγ induce the production of Alzheimer β-amyloid peptides and decrease the secretion of APPs
    Blasko, I
    Marx, F
    Steiner, E
    Hartmann, T
    Grubeck-Loebenstein, B
    [J]. FASEB JOURNAL, 1999, 13 (01) : 63 - 68
  • [7] Combs CK, 2001, J NEUROSCI, V21, P1179
  • [8] Key issues in Alzheimer's disease inflammation - Response
    Cooper, NR
    Kalaria, RN
    McGeer, PL
    Rogers, J
    [J]. NEUROBIOLOGY OF AGING, 2000, 21 (03) : 451 - 453
  • [9] Tumour necrosis factor-α gene polymorphisms and Alzheimer's disease
    Culpan, D
    MacGowan, SH
    Ford, JM
    Nicoll, JAR
    Griffin, WS
    Dewar, D
    Cairns, NJ
    Hughes, A
    Kehoe, PG
    Wilcock, GK
    [J]. NEUROSCIENCE LETTERS, 2003, 350 (01) : 61 - 65
  • [10] TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases
    Feldmann, M
    Maini, RN
    [J]. NATURE MEDICINE, 2003, 9 (10) : 1245 - 1250
1234