TGF-β signaling:: positive and negative effects on tumorigenesis

被引：688
作者：
Wakefield, LM [1 ]
Roberts, AB [1 ]
机构：
[1] NCI, Lab Cell Regulat & Carcinogenesis, Bethesda, MD 20892 USA
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 2002年 / 12卷 / 01期
关键词：
D O I：
10.1016/S0959-437X(01)00259-3
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
TGF-beta binding to the cell surface triggers activation of multiple signal transduction pathways that are connected in intricate ways with each other, and with other response networks involved in sensing cellular information input. Recent data indicate that changes in signal intensity and connectivity of these pathways may underlie the complex transition of the TGF-beta pathway from tumor suppressor to oncogene during tumorigenesis.
引用
收藏
页码：22 / 29
页数：8
相关论文
共 63 条
[61]  
Yu Q, 2000, GENE DEV, V14, P163
[62]   Genetic programs of epithelial cell plasticity directed by transforming growth factor-β [J].
Zavadil, J ;
Bitzer, M ;
Liang, D ;
Yang, YC ;
Massimi, A ;
Kneitz, S ;
Piek, E ;
Böttinger, EP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (12) :6686-6691
[63]   Association between the T29→C polymorphism in the transforming growth factor β1 gene and breast cancer among elderly white women the study of osteoporotic fractures [J].
Ziv, E ;
Cauley, J ;
Morin, PA ;
Saiz, R ;
Browner, WS .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 285 (22) :2859-2863
1234567