How to guarantee the security of structures and prevent structural progressive collapse caused by local column failure under accident load have been drawn wide attention from the engineering community. Based on the DoD2005 standard, this paper analyzes the influence of local column failure on multilayer RC frame structure by an example, examines the influence of local frame structure column failure on various performance parameters, such as structure periods, ultimate bearing capacity, safety storage and so on, and based on method of vertical nonlinear dynamic analysis, it analyzes the capability of integrally resisting progressive collapse after frame structure short side column is failure.