Neural computational modeling reveals a major role of corticospinal gating of central oscillations in the generation of essential tremor

被引：4

作者：

Qu, Hong-en ^{[1
]}

Niu, Chuanxin M. ^{[1
,2
]}

Li, Si ^{[1
]}

Hao, Man-zhao ^{[1
]}

Hu, Zi-xiang ^{[1
]}

Xie, Qing ^{[2
]}

Lan, Ning ^{[1
,3
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Biomed Engn, Lab Neurorehabil Engn, Shanghai, Peoples R China

[2] Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Rehabil Med, Shanghai, Peoples R China

[3] Univ Southern Calif, Ostrow Sch Dent, Div Biokinesiol & Phys Therapy, Los Angeles, CA 90007 USA

来源：

NEURAL REGENERATION RESEARCH | 2017年 / 12卷 / 12期

基金：

中国国家自然科学基金;

关键词：

nerve regeneration; neurodegeneration; essential tremor; propriospinal neurons; motoneuron; reflex; modeling; motor control; oscillation; neurological disorder; movement disorder; computational neuroscience; neural regeneration; MOTOR CONTROL; MATHEMATICAL-MODELS; DECEREBRATE CAT; MACAQUE MONKEY; MOVEMENT; LOCOMOTION; FREQUENCY; AMPLITUDE; SYSTEM; PROPRIOCEPTORS;

D O I：

10.4103/1673-5374.221161

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Essential tremor, also referred to as familial tremor, is an autosomal dominant genetic disease and the most common movement disorder. It typically involves a postural and motor tremor of the hands, head or other part of the body. Essential tremor is driven by a central oscillation signal in the brain. However, the corticospinal mechanisms involved in the generation of essential tremor are unclear. Therefore, in this study, we used a neural computational model that includes both monosynaptic and multisynaptic corticospinal pathways interacting with a propriospinal neuronal network. A virtual arm model is driven by the central oscillation signal to simulate tremor activity behavior. Cortical descending commands are classified as alpha or gamma through monosynaptic or multisynaptic corticospinal pathways, which converge respectively on alpha or gamma motoneurons in the spinal cord. Several scenarios are evaluated based on the central oscillation signal passing down to the spinal motoneurons via each descending pathway. The simulated behaviors are compared with clinical essential tremor characteristics to identify the corticospinal pathways responsible for transmitting the central oscillation signal. A propriospinal neuron with strong cortical inhibition performs a gating function in the generation of essential tremor. Our results indicate that the propriospinal neuronal network is essential for relaying the central oscillation signal and the production of essential tremor.

引用

页码：2035 / 2044

页数：10