An Implantable Microsystem for Tonometric Blood Pressure Measurement

被引：41

作者：

Ziaie, Babak ^{[1
]}

Najafi, Khalil ^{[2
,3
]}

机构：

[1] Univ Minnesota, Dept Elect & Comp Engn, Minneapolis, MN 55455 USA

[2] Univ Michigan, Dept Elect Engn, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Comp Sci Ctr Integrated Microsyst, Ann Arbor, MI 48109 USA

来源：

BIOMEDICAL MICRODEVICES | 2001年 / 3卷 / 04期

基金：

美国国家航空航天局;

关键词：

implantable microsystems; tonometry; bioMEMS; biomedical microdevices; blood pressure measurement; biomedical transducers;

D O I：

10.1023/A:1012452613720

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

This paper presents an implantable microsystem for tonometric blood pressure measurement in small animals. The microsystem consists of four major components: (1) a titanium base for supporting a pressure sensor and an interface chip, (2) a micromachined capacitive pressure sensor array, (3) a switched-capacitor interface chip, and (4) a titanium cap. A new micromachining fabrication process has been developed to create capacitive pressure transducers with a flat surface necessary for tonometric pressure measurement. An array of three capacitive sensors is used to increase signal output and improve stability. A custom-designed switched-capacitor CMOS interface circuit is used to measure changes in capacitance. In vitro calibration tests have been performed on the complete cuff using a silastic tube to mimic a pliable blood vessel. A sensitivity of 2 mV/mmHg @ 100 mmHg and a resolution of 0.5 mmHg (based on 1 mV RMS interface chip noise floor) has been obtained. The dimensions of the cuff system 10(L) x 6.5(W) x 3(11) mm(3).

引用

页码：285 / 292

页数：8

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