Epstein-Barr virus-associated gastric carcinoma and atrophic gastritis

被引:43
|
作者
Yanai, H
Murakami, T
Yoshiyama, H
Takeuchi, H
Nishikawa, J
Nakamura, H
Okita, K
Miura, O
Shimizu, N
Takada, K
机构
[1] Yamaguchi Univ, Sch Med, Dept Internal Med 1, Ube, Yamaguchi 7558505, Japan
[2] Yamaguchi Univ, Sch Med, Dept Pathol 2, Ube, Yamaguchi 7558505, Japan
[3] Yamaguchi Univ, Sch Med, Dept Microbiol, Ube, Yamaguchi 7558505, Japan
[4] Tokyo Med & Dent Univ, Med Res Inst, Dept Virol, Tokyo, Japan
[5] Hokkaido Univ, Sch Med, Inst Canc, Dept Virol, Sapporo, Hokkaido 060, Japan
关键词
atrophic gastritis; gastric carcinoma; Epstein-Barr virus;
D O I
10.1097/00004836-199907000-00010
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Although Epstein-Barr virus (EBV) has been reported to be present in some 7% of gastric carcinomas, the nature of the background gastric mucosa of carcinoma has not been elucidated. The authors evaluated the degree of gastritis in the background gastric mucosa of EBV-associated gastric carcinoma. EBV was detected using in situ hybridization for EBV-encoded small ribonucleic acid 1 (EBER-1) in carcinoma cells. The authors compared gastritis in surgically resected stomachs with 8 EBER-1-positive and 16 EBER-1-negative gastric carcinomas of a similar histologic type using histologic variables of the Updated Sydney System. All eight lesions of EBER-1-positive gastric carcinomas had intestinal metaplasia in the background. Mild to moderate glandular atrophy was common in both groups. Many of the tested lesions, 87.5% of EBER-1-positive and 62.5% of EBER-1-negative lesions, were located near the mucosal atrophic border. The background gastric mucosa for EBV-associated gastric carcinomas is rich in atrophic changes. EBV-associated gastric carcinomas are located near the mucosal atrophic border.
引用
收藏
页码:39 / 43
页数:5
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